机构:Northwestern Univ, Ctr Funct Genomics, Evanston, IL 60208 USA
Vitaterna, MH
Takahashi, JS
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机构:
Northwestern Univ, Ctr Funct Genomics, Evanston, IL 60208 USANorthwestern Univ, Ctr Funct Genomics, Evanston, IL 60208 USA
Takahashi, JS
[1
]
Turek, FW
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机构:Northwestern Univ, Ctr Funct Genomics, Evanston, IL 60208 USA
Turek, FW
机构:
[1] Northwestern Univ, Ctr Funct Genomics, Evanston, IL 60208 USA
[2] Northwestern Univ, Dept Neurobiol & Physiol, Evanston, IL 60208 USA
[3] Northwestern Univ, Howard Hughes Med Inst, Evanston, IL 60208 USA
[4] Northwestern Univ, Ctr Sleep & Circadian Biol, Evanston, IL USA
来源:
ALCOHOL RESEARCH & HEALTH
|
2001年
/
25卷
/
02期
关键词:
circadian rhythm;
time of day;
biological regulation;
biological adaptation;
temperature;
light;
hypothalamus;
neural cell;
gene expression;
mutagenesis;
sleep disorder;
physiological AODE (effects of alcohol or other drug use;
abuse;
and dependence);
D O I:
暂无
中图分类号:
R194 [卫生标准、卫生检查、医药管理];
学科分类号:
摘要:
The daily light-dark cycle governs rhythmic changes in the behavior and/or physiology of most species. Studies have found that these changes are governed by a biological clock, which in mammals is located in two brain areas called the suprachiasmatic nuclei. The circadian cycles established by this clock occur throughout nature and have a period of approximately 24 hours. In addition, these circadian cycles can be synchronized to external time signals but also can persist in the absence of such signals. Studies have found that the internal clock consists of an array of genes and the protein products they encode, which regulate various physiological processes throughout the body. Disruptions of the biological rhythms can impair the health and well-being of the organism.
机构:
Univ Calif Los Angeles, Sch Med, Div Hematol Oncol, Cedars Sinai Med Ctr, Los Angeles, CA 90024 USAUniv Calif Los Angeles, Sch Med, Div Hematol Oncol, Cedars Sinai Med Ctr, Los Angeles, CA 90024 USA
Gery, Sigal
Koeffler, H. Phillip
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机构:
Univ Calif Los Angeles, Sch Med, Div Hematol Oncol, Cedars Sinai Med Ctr, Los Angeles, CA 90024 USA
Natl Univ Singapore, Singapore 117548, SingaporeUniv Calif Los Angeles, Sch Med, Div Hematol Oncol, Cedars Sinai Med Ctr, Los Angeles, CA 90024 USA
机构:
Univ Nebraska, Sch Vet Med & Biomed Sci, Lincoln, NE 68583 USAUniv Nebraska, Sch Vet Med & Biomed Sci, Lincoln, NE 68583 USA
Sollars, Patricia J.
Pickard, Gary E.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Nebraska, Sch Vet Med & Biomed Sci, Lincoln, NE 68583 USA
Univ Nebraska Med Ctr, Dept Ophthalmol & Visual Sci, Omaha, NE 68198 USAUniv Nebraska, Sch Vet Med & Biomed Sci, Lincoln, NE 68583 USA
机构:
Brigham & Womens Hosp, Dept Med, Div Sleep & Circadian Disorders, Boston, MA 02115 USA
Brigham & Womens Hosp, Dept Neurol, Div Sleep & Circadian Disorders, Boston, MA 02115 USA
Harvard Med Sch, Div Sleep Med, Boston, MA USABrigham & Womens Hosp, Dept Med, Div Sleep & Circadian Disorders, Boston, MA 02115 USA
Duffy, Jeanne F.
Zitting, Kirsi-Marja
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h-index: 0
机构:
Brigham & Womens Hosp, Dept Med, Div Sleep & Circadian Disorders, Boston, MA 02115 USA
Brigham & Womens Hosp, Dept Neurol, Div Sleep & Circadian Disorders, Boston, MA 02115 USA
Harvard Med Sch, Div Sleep Med, Boston, MA USABrigham & Womens Hosp, Dept Med, Div Sleep & Circadian Disorders, Boston, MA 02115 USA
Zitting, Kirsi-Marja
Chinoy, Evan D.
论文数: 0引用数: 0
h-index: 0
机构:
Brigham & Womens Hosp, Dept Med, Div Sleep & Circadian Disorders, Boston, MA 02115 USA
Brigham & Womens Hosp, Dept Neurol, Div Sleep & Circadian Disorders, Boston, MA 02115 USA
Harvard Med Sch, Div Sleep Med, Boston, MA USABrigham & Womens Hosp, Dept Med, Div Sleep & Circadian Disorders, Boston, MA 02115 USA