Synthesis of certain 1,3,4-oxadiazoles as potential antitubercular and antimicrobial agents

被引：0
|
作者：
Dhol, SR [1 ]
Bhimani, AS [1 ]
Khunt, RC [1 ]
Parikh, AR [1 ]
机构：
[1] Saurashtra Univ, Dept Chem, Rajkot 360005, Gujarat, India
来源：
INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY | 2005年 / 15卷 / 01期
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D O I：
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中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Diphenyl acetic acid 1 on esterification gave ethyl diphenyl acetate 2, which on reaction with hydrazine hydrate yielded starting compound diphenyl aceto hydrazide 3. The heterocyclisation of 3 with different aromatic acids in presence of phosphorusoxy chloride yielded target molecules 4a-o. All the compounds were screened for their antitubercular activity against Mycobacterium tuberculosis H-37 Rv and antimicrobial activity against different strains of bacteria and fungi.
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页码：63 / 64
页数：2
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