Hydrolysis of DNA by N-phosphoryl branched peptide

被引：3
|
作者：
Xiao, AS
Yang, J
Feng, YP [1 ]
Cao, SL
Zhao, YF
机构：
[1] Tsinghua Univ, Minist Educ, Key Lab Bioorgan Phosphorus & Chem Biol, Beijing 100084, Peoples R China
[2] Capital Normal Univ, Dept Chem, Beijing, Peoples R China
来源：
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS | 2005年 / 180卷 / 08期
基金：
中国国家自然科学基金;
关键词：
branched peptide; DNA cleavage; hydrolysis; n-phosphorylation;
D O I：
10.1080/104265090902705
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
A N-phosphoryl branched peptide (DIPP-Leu)(2)-Lys-OCH3 was found to efficiently cleave double-strand DNA such as PUC19 and Lambda DNA at pH 8.5 in 100 mM Tris-HCl buffer The T4 ligase experiment implied that the DNA cleavage occurs via a hydrolytic path.
引用
收藏
页码：1947 / 1951
页数：5
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