Inhibition of Mammary Tumor Growth Using Lysyl Oxidase-Targeting Nanoparticles to Modify Extracellular Matrix

被引：95
|
作者：
Kanapathipillai, Mathumai [1 ]
Mammoto, Akiko [2 ,3 ,4 ]
Mammoto, Tadanori [2 ,3 ,4 ]
Kang, Joo H. [1 ]
Jiang, Elisabeth [2 ,3 ,4 ]
Ghosh, Kaustabh [2 ,3 ,4 ]
Korin, Netanel [1 ]
Gibbs, Ashley [2 ,3 ,4 ]
Mannix, Robert [2 ,3 ,4 ]
Ingber, Donald E. [1 ,2 ,3 ,4 ,5 ]
机构：
[1] Harvard Univ, Wyss Inst Biol Inspired Engn, Boston, MA 02115 USA
[2] Childrens Hosp, Dept Pathol, Vasc Biol Program, Boston, MA 02115 USA
[3] Childrens Hosp, Dept Surg, Vasc Biol Program, Boston, MA 02115 USA
[4] Harvard Univ, Sch Med, Boston, MA 02115 USA
[5] Harvard Univ, Sch Engn & Appl Sci, Cambridge, MA 02138 USA
来源：
NANO LETTERS | 2012年 / 12卷 / 06期
关键词：
Cancer; nanoparticle; lysyl oxidase; extracellular matrix; mechanics; PLGA NANOPARTICLES; CANCER; CLEARANCE;
D O I：
10.1021/nl301206p
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A cancer nanotherapeutic has been developed that targets the extracellular matrix (ECM)-modifying enzyme lysyl oxidase (LOX) and alters the ECM structure. Poly(D,L-lactide-co-glycolide) nanoparticles (similar to 220 nm) coated with a LOX inhibitory antibody bind to ECM and suppress mammary cancer cell growth and invasion in vitro as well as tumor expansion in vivo, with greater efficiency than soluble anti-LOX antibody. This nanomaterials approach opens a new path for treating cancer with higher efficacy and decreased side effects.
引用
收藏
页码：3213 / 3217
页数：5
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