Inhibition of Mammary Tumor Growth Using Lysyl Oxidase-Targeting Nanoparticles to Modify Extracellular Matrix

被引：95

作者：

Kanapathipillai, Mathumai ^{[1
]}

Mammoto, Akiko ^{[2
,3
,4
]}

Mammoto, Tadanori ^{[2
,3
,4
]}

Kang, Joo H. ^{[1
]}

Jiang, Elisabeth ^{[2
,3
,4
]}

Ghosh, Kaustabh ^{[2
,3
,4
]}

Korin, Netanel ^{[1
]}

Gibbs, Ashley ^{[2
,3
,4
]}

Mannix, Robert ^{[2
,3
,4
]}

Ingber, Donald E. ^{[1
,2
,3
,4
,5
]}

机构：

[1] Harvard Univ, Wyss Inst Biol Inspired Engn, Boston, MA 02115 USA

[2] Childrens Hosp, Dept Pathol, Vasc Biol Program, Boston, MA 02115 USA

[3] Childrens Hosp, Dept Surg, Vasc Biol Program, Boston, MA 02115 USA

[4] Harvard Univ, Sch Med, Boston, MA 02115 USA

[5] Harvard Univ, Sch Engn & Appl Sci, Cambridge, MA 02138 USA

来源：

NANO LETTERS | 2012年 / 12卷 / 06期

关键词：

Cancer; nanoparticle; lysyl oxidase; extracellular matrix; mechanics; PLGA NANOPARTICLES; CANCER; CLEARANCE;

D O I：

10.1021/nl301206p

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A cancer nanotherapeutic has been developed that targets the extracellular matrix (ECM)-modifying enzyme lysyl oxidase (LOX) and alters the ECM structure. Poly(D,L-lactide-co-glycolide) nanoparticles (similar to 220 nm) coated with a LOX inhibitory antibody bind to ECM and suppress mammary cancer cell growth and invasion in vitro as well as tumor expansion in vivo, with greater efficiency than soluble anti-LOX antibody. This nanomaterials approach opens a new path for treating cancer with higher efficacy and decreased side effects.

引用

页码：3213 / 3217

页数：5

共 42 条

[21] Impact of tumor-specific targeting and dosing schedule on tumor growth inhibition after intravenous administration of siRNA-containing nanoparticles
Bartlett, Derek W.
Davis, Mark E.
BIOTECHNOLOGY AND BIOENGINEERING, 2008, 99 (04) : 975 - 985
[22] A MODEL FOR GROWTH ENHANCEMENT AND INHIBITION OF HUMAN TUMOR-CELL LINES IN ATHYMIC MICE WITH A HUMAN EXTRACELLULAR-MATRIX
GOODLY, LJ
SINGH, RK
WANG, MH
KENNEDY, JW
SLEGAL, GP
MOLECULAR BIOLOGY OF THE CELL, 1992, 3 : A77 - A77
[23] EFFECTS OF EXTRACELLULAR-MATRIX ON THE GROWTH AND CASEIN GENE-EXPRESSION OF PRIMARY MOUSE MAMMARY-TUMOR CELLS-INVITRO
CHOU, JL
SHEN, ZX
STOLFI, RL
MARTIN, DS
WAXMAN, S
CANCER RESEARCH, 1989, 49 (19) : 5371 - 5376
[24] Noninvasive imaging of tumor progression, metastasis, and fibrosis using a nanobody targeting the extracellular matrix (vol 116, pg 14181, 2019)
Jailkhani, Noor
Ingram, Jessica R.
Rashidian, Mohammad
Rickelt, Steffen
Tian, Chenxi
Mak, Howard
Jiang, Zhigang
Ploegh, Hidde L.
Hynes, Richard O.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2019, 116 (37) : 18745 - 18745
[25] Transforming Growth Factor-β Induces Extracellular Matrix Protein Cross-Linking Lysyl Oxidase (LOX) Genes in Human Trabecular Meshwork Cells (vol 52, pg 5240, 2011)
Sethi, Anirudh
Mao, Weiming
Wordinger, Robert J.
Clark, Abbot F.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2013, 54 (03) : 1705 - 1705
[26] Inhibition of vimentin or β1 integrin revert morphology of prostate tumor cells grown in laminin-rich extracellular matrix gels and reduces tumor growth in vivo
Zhang, Xueping
Fournier, Marcia V.
Ware, Joy L.
Bissell, Mina J.
Yacoub, Adly
Zehner, Zendra E.
MOLECULAR CANCER THERAPEUTICS, 2009, 8 (03) : 499 - 508
[27] Inhibition of PlexA1-mediated brain tumor growth and tumor-associated angiogenesis using a transmembrane domain targeting peptide
Jacob, Laurent
Sawma, Paul
Garnier, Norbert
Meyer, Lionel A. T.
Fritz, Justine
Hussenet, Thomas
Spenle, Caroline
Goetz, Jacky
Vermot, Julien
Fernandez, Aurore
Baumlin, Nadege
Aci-Seche, Samia
Orend, Gertraud
Roussel, Guy
Cremel, Gerard
Genest, Monique
Hubert, Pierre
Bagnard, Dominique
ONCOTARGET, 2016, 7 (36) : 57851 - 57865
[28] Inhibition of Notch4 Using Novel Neutralizing Antibodies Reduces Tumor Growth in Murine Cancer Models by Targeting the Tumor Endothelium
Eng, Jason W. -L.
Kato, Yu
Adachi, Yusuke
Swaminathan, Bhairavi
Naiche, L. A.
Vadakath, Rahul
Sakamoto, Yoshimasa
Nakazawa, Youya
Tachino, Sho
Ito, Ken
Abe, Takanori
Minoshima, Yukinori
Hoshino-Negishi, Kana
Ogasawara, Hideaki
Kawakatsu, Tomomi
Nishimura, Miyuki
Katayama, Masahiko
Shimizu, Masashi
Tahara, Kazuhiro
Sato, Toshitaka
Suzuki, Katsuhisa
Agarwala, Kishan
Iwata, Masao
Nomoto, Kenichi
Ozawa, Yoichi
Imai, Toshio
Funahashi, Yasuhiro
Matsui, Junji
Kitajewski, Jan
CANCER RESEARCH COMMUNICATIONS, 2024, 4 (07): : 1881 - 1893
[29] Inhibition of tumor growth and vasculature and fluorescence imaging using functiOnalized ruthenium-thiol protected selenium nanoparticles
Sun, Dongdong
Liu, Yanan
Yu, Qianqian
Qin, Xiuying
Yang, Licong
Zhou, Yanhui
Chen, Lanmei
Liu, Jie
BIOMATERIALS, 2014, 35 (05) : 1572 - 1583
[30] Extracellular matrix remodeling in vivo for enhancing tumor-targeting efficiency of nanoparticle drug carriers using the pulsed high intensity focused ultrasound
Lee, Sangmin
Han, Hyounkoo
Koo, Heebeom
Na, Jin Hee
Yoon, Hong Yeol
Lee, Kyung Eun
Lee, Hyukjin
Kim, Hyuncheol
Kwon, Ick Chan
Kim, Kwangmeyung
JOURNAL OF CONTROLLED RELEASE, 2017, 263 : 68 - 78

← 1 2 3 4 5 →