Inhibition of Mammary Tumor Growth Using Lysyl Oxidase-Targeting Nanoparticles to Modify Extracellular Matrix

被引：95

作者：

Kanapathipillai, Mathumai ^{[1
]}

Mammoto, Akiko ^{[2
,3
,4
]}

Mammoto, Tadanori ^{[2
,3
,4
]}

Kang, Joo H. ^{[1
]}

Jiang, Elisabeth ^{[2
,3
,4
]}

Ghosh, Kaustabh ^{[2
,3
,4
]}

Korin, Netanel ^{[1
]}

Gibbs, Ashley ^{[2
,3
,4
]}

Mannix, Robert ^{[2
,3
,4
]}

Ingber, Donald E. ^{[1
,2
,3
,4
,5
]}

机构：

[1] Harvard Univ, Wyss Inst Biol Inspired Engn, Boston, MA 02115 USA

[2] Childrens Hosp, Dept Pathol, Vasc Biol Program, Boston, MA 02115 USA

[3] Childrens Hosp, Dept Surg, Vasc Biol Program, Boston, MA 02115 USA

[4] Harvard Univ, Sch Med, Boston, MA 02115 USA

[5] Harvard Univ, Sch Engn & Appl Sci, Cambridge, MA 02138 USA

来源：

NANO LETTERS | 2012年 / 12卷 / 06期

关键词：

Cancer; nanoparticle; lysyl oxidase; extracellular matrix; mechanics; PLGA NANOPARTICLES; CANCER; CLEARANCE;

D O I：

10.1021/nl301206p

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A cancer nanotherapeutic has been developed that targets the extracellular matrix (ECM)-modifying enzyme lysyl oxidase (LOX) and alters the ECM structure. Poly(D,L-lactide-co-glycolide) nanoparticles (similar to 220 nm) coated with a LOX inhibitory antibody bind to ECM and suppress mammary cancer cell growth and invasion in vitro as well as tumor expansion in vivo, with greater efficiency than soluble anti-LOX antibody. This nanomaterials approach opens a new path for treating cancer with higher efficacy and decreased side effects.

引用

页码：3213 / 3217

页数：5

共 42 条

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