Toxicological effects of multi-wall carbon nanotubes in rats

被引：57
|
作者：
Liu, Aihong [1 ]
Sun, Kangning [1 ]
Yang, Jiafeng [1 ,2 ]
Zhao, Dongmei [2 ]
机构：
[1] Shandong Univ, Inst Mat Sci & Engn, Engn Ceram Key Lab Shandong Prov, Key Lab Liquid Struct & Hered Mat,Minist Educ, Jinan 250061, Shandong, Peoples R China
[2] Shandong Univ, Hosp 2, Jinan 250070, Shandong, Peoples R China
来源：
JOURNAL OF NANOPARTICLE RESEARCH | 2008年 / 10卷 / 08期
关键词：
multi-wall carbon nanotubes; lung toxicity; nanomaterials; intratracheal instillation; MWCNT; nanomedicine;
D O I：
10.1007/s11051-008-9369-0
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The aim of this study was to evaluate the lung toxicity of multi-wall carbon nanotubes (MWCNTs). The present work exposed MWCNTs into the rats in intratracheal instillation administration modes. We systematically studied the distribution of nanoparticles in vivo, target organs and time-effects of nanotoxicity, dose-effects of nanotoxicity, etc. These results indicate that under the conditions of this test, pulmonary exposures to MWCNTs in rats by intratracheal instillation produced a series of multiple lesions in a dose-dependent and time-dependent manner, evidence of a foreign tissue body reaction.
引用
收藏
页码：1303 / 1307
页数：5
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