Uncoupling protein 2: Adiposity angel and diabetes devil?

被引：14
|
作者：
O'Rahilly, S [1 ]
机构：
[1] Univ Cambridge, Addenbrookes Hosp, Cambridge CB2 2QQ, England
来源：
NATURE MEDICINE | 2001年 / 7卷 / 07期
关键词：
D O I：
10.1038/89877
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The discovery of a family of proteins with strong homology to the uncoupling protein of brown fat has generated great interest as these molecules might represent therapeutic targets for human obesity. Two recent studies have used genetics to explore the role of one of these proteins, UCP2, in the control of mammalian metabolism and come to rather different conclusions.
引用
收藏
页码：770 / 772
页数：3
相关论文
共 50 条
  • [41] SIBLING DEIDENTIFICATION IN THE CLINIC - DEVIL VS ANGEL
    SCHACHTER, FF
    FAMILY PROCESS, 1985, 24 (03) : 415 - 427
  • [42] Uncoupling protein 2 genotype and incident diabetes: The Atherosclerosis Risk in Communities Study (ARIC).
    Bielinski, S. J.
    Pankow, J. S.
    Boerwinkle, E.
    Bray, M. S.
    Kao, W. H. L.
    Folsom, A. R.
    AMERICAN JOURNAL OF EPIDEMIOLOGY, 2006, 163 (11) : S129 - S129
  • [43] Uncoupling protein 3 content is decreased in skeletal muscle of patients with type 2 diabetes
    Schrauwen, P
    Hesselink, MKC
    Blaak, EE
    Borghouts, LB
    Schaart, G
    Saris, WHM
    Keizer, HA
    DIABETES, 2001, 50 (12) : 2870 - 2873
  • [44] Mitochondrial uncoupling protein UCP2 influences type 1 diabetes development
    Emre, Y.
    Hurtaud, C.
    Karaca, M.
    Nubel, T.
    Zavala, F.
    Ricquier, D.
    DIABETOLOGIA, 2007, 50 : S184 - S184
  • [45] Effects of 2 G on adiposity, leptin, lipoprotein lipase, and uncoupling protein-1 in lean and obese Zucker rats
    Warren, LE
    Horwitz, BA
    Hamilton, JS
    Fuller, CA
    JOURNAL OF APPLIED PHYSIOLOGY, 2001, 90 (02) : 606 - 614
  • [46] Uncoupling protein 2, but not uncoupling protein 1, is expressed in the female mouse reproductive tract
    Rousset, S
    Alves-Guerra, MC
    Ouadghiri-Bencherif, S
    Kozak, LP
    Miroux, B
    Richard, D
    Bouillaud, F
    Ricquier, D
    Cassard-Doulcier, AM
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (46) : 45843 - 45847
  • [47] Uncoupling protein-2 and cancer
    Baffy, Gyorgy
    MITOCHONDRION, 2010, 10 (03) : 243 - 252
  • [48] Uncoupling protein 2 and islet function
    Chan, CB
    Saleh, MC
    Koshkin, V
    Wheeler, MB
    DIABETES, 2004, 53 : S136 - S142
  • [49] Uncoupling protein 2 and metabolic diseases
    Sreedhar, Annapoorna
    Zhao, Yunfeng
    MITOCHONDRION, 2017, 34 : 135 - 140
  • [50] Angel and Devil Robots: Personifying a Dilemma to Influence Willpower
    Goto, Kento
    Mizumaru, Kazuki
    Sakamoto, Daisuke
    Ono, Tetsuo
    PROCEEDINGS OF THE 10TH CONFERENCE ON HUMAN-AGENT INTERACTION, HAI 2022, 2022, : 260 - 262
12345