Uncoupling protein 2: Adiposity angel and diabetes devil?

被引：14
|
作者：
O'Rahilly, S [1 ]
机构：
[1] Univ Cambridge, Addenbrookes Hosp, Cambridge CB2 2QQ, England
来源：
NATURE MEDICINE | 2001年 / 7卷 / 07期
关键词：
D O I：
10.1038/89877
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The discovery of a family of proteins with strong homology to the uncoupling protein of brown fat has generated great interest as these molecules might represent therapeutic targets for human obesity. Two recent studies have used genetics to explore the role of one of these proteins, UCP2, in the control of mammalian metabolism and come to rather different conclusions.
引用
收藏
页码：770 / 772
页数：3
相关论文
共 50 条
  • [21] Uncoupling protein 2 promoter polymorphism-866G/A, central adiposity, and metabolic syndrome in Asians
    Shen, Haiqing
    Qi, Lu
    Tai, E. Shyong
    Chew, Suok Kai
    Tan, Chee Eng
    Ordovas, Jose M.
    OBESITY, 2006, 14 (04) : 656 - 661
  • [22] ANGEL-HO, "RED DEVIL"
    Angel-Ho
    ARTFORUM INTERNATIONAL, 2016, 55 (04): : 75 - 75
  • [23] THE VACUUM MACHINE + LAUGHTER OF THE ANGEL AND OF THE DEVIL
    PREZZO, R
    AUT AUT, 1984, (201): : 15 - 31
  • [24] Uncoupling protein-2 polymorphisms in type 2 diabetes, obesity, and insulin secretion
    Wang, H
    Chu, WS
    Lu, T
    Hasstedt, SJ
    Kern, PA
    Elbein, SC
    AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2004, 286 (01): : E1 - E7
  • [25] The role of uncoupling protein 1 in the metabolism and adiposity of RIIβ-protein kinase A-deficient mice
    Nolan, MA
    Sikorski, MA
    McKnight, GS
    MOLECULAR ENDOCRINOLOGY, 2004, 18 (09) : 2302 - 2311
  • [26] The H2 molecule in semiconductors:: An angel in GaAs, a devil in Si
    Estreicher, SK
    ACTA PHYSICA POLONICA A, 2002, 102 (4-5) : 513 - 528
  • [27] Lipocalin 2-Devil or Angel? A pan cancer study.
    Srinivasalu, Vijay Kumar
    Subramaniam, Narayana
    Das, Manjula
    Dhar, Sujan Kumar
    JOURNAL OF CLINICAL ONCOLOGY, 2020, 38 (15)
  • [28] Uncoupling Protein 2 and 3 Gene Polymorphisms and Their Association with Type 2 Diabetes in Asian Indians
    Vimaleswaran, Karani S.
    Radha, Venkatesan
    Ghosh, Saurabh
    Majumder, Partha P.
    Rao, Manchanahalli R. Sathyanarayana
    Mohan, Viswanathan
    DIABETES TECHNOLOGY & THERAPEUTICS, 2011, 13 (01) : 19 - 25
  • [29] Lucifer yellow - an angel rather than the devil
    Hanani, Menachem
    JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2012, 16 (01) : 22 - 31
  • [30] Bone morphogenetic proteins in melanoma: Angel or devil?
    Hsu, MY
    Rovinsky, S
    Penmatcha, S
    Herlyn, M
    Muirhead, D
    CANCER AND METASTASIS REVIEWS, 2005, 24 (02) : 251 - 263
12345