Mitotic Spindle as Therapeutic Target for Tetraploid Cancer Cells

被引：4
|
作者：
Jemaa, Mohamed [1 ]
机构：
[1] Lund Univ, Fac Med, Dept Lab Med, Translat Canc Res, Lund, Sweden
来源：
EURASIAN JOURNAL OF MEDICINE AND ONCOLOGY | 2021年 / 5卷 / 03期
关键词：
Centrosome Apparatus; Tetraploidy; Spindle Assembly Checkpoint; Mitotic Catastrophe; CHROMOSOMAL INSTABILITY; ASSEMBLY CHECKPOINT; TUMOR-CELLS; ANEUPLOIDY; KINASE; CONSEQUENCES; SENSITIVITY; MECHANISM;
D O I：
10.14744/ejmo.2021.13872
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Tetraploidy constitutes a genomically metastable state that drives oncogenesis by leading aneuploidy. Tetraploid sub-population is frequently found in pre-neoplastic lesions. This particular population is relatively more resistant against DNA damaging agents and in consequence, it is important to selectively target tetraploid cancer cells. Here, we listed all the studies that targeted preferentially tetraploid tumors cells focusing on mitosis machinery, essentially the spindle pole apparatus and the spindle assembly checkpoint pathways.
引用
收藏
页码：205 / 208
页数：4
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