Mitotic Spindle as Therapeutic Target for Tetraploid Cancer Cells

Tetraploidy constitutes a genomically metastable state that drives oncogenesis by leading aneuploidy. Tetraploid sub-population is frequently found in pre-neoplastic lesions. This particular population is relatively more resistant against DNA damaging agents and in consequence, it is important to selectively target tetraploid cancer cells. Here, we listed all the studies that targeted preferentially tetraploid tumors cells focusing on mitosis machinery, essentially the spindle pole apparatus and the spindle assembly checkpoint pathways.