Combined Raman spectroscopy and optical coherence tomography device for tissue characterization

被引：92

作者：

Patil, Chetan A. ^{[1
]}

Bosschaart, Nienke ^{[2
,3
]}

Keller, Matthew D. ^{[1
]}

van Leeuwen, Ton G. ^{[2
,3
]}

Mahadevan-Jansen, Anita ^{[1
]}

机构：

[1] Vanderbilt Univ, Dept Biomed Engn, Nashville, TN 37235 USA

[2] Univ Twente, Fac Sci & Technol, Biophys Engn Grp, NL-7500 AE Enschede, Netherlands

[3] Univ Amsterdam, Acad Med Ctr, Ctr Laser, NL-1100 DD Amsterdam, Netherlands

来源：

OPTICS LETTERS | 2008年 / 33卷 / 10期

关键词：

D O I：

10.1364/OL.33.001135

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

We report a dual-modal device capable of sequential acquisition of Raman spectroscopy (RS) and optical coherence tomography (OCT) along a common optical axis. The device enhances application of both RS and OCT by precisely guiding RS acquisition with OCT images while also compensating for the lack of molecular specificity in OCT with the biochemical specificity of RS. We characterize the system performance and demonstrate the capability to identify structurally ambiguous features within an OCT image with RS in a scattering phantom, guide acquisition of RS from a localized malignancy in ex vivo breast tissue, and perform in vivo tissue analysis of a scab. (C) 2008 Optical Society of America.

引用

页码：1135 / 1137

页数：3

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