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Oxyfold: A Simple and Efficient Solid-Supported Reagent for Disulfide Bond Formation
被引:10
|作者:
Verdie, Pascal
[1
]
Ronga, Luisa
[2
]
Cristau, Michele
[1
,2
]
Amblard, Muriel
[1
]
Cantel, Sonia
[1
]
Enjalbal, Christine
[1
]
Puget, Karine
[2
]
Martinez, Jean
[1
]
Subra, Gilles
[1
]
机构:
[1] CNRS, IBMM, UMR 5247, F-34000 Montpellier, France
[2] Genepep, Domaine Pins, F-34980 St Clement De Riviere, France
关键词:
amino acids;
methionine;
oxidation;
peptides;
supported reagents;
PHASE PEPTIDE-SYNTHESIS;
SOMATOSTATIN;
ANALOG;
D O I:
10.1002/asia.201100202
中图分类号:
O6 [化学];
学科分类号:
0703 ;
摘要:
The synthesis and use of novel polymer-supported reagents for disulfide bond formation is described. This family of supported reagents consists of a series of oxidized methionines grafted onto a solid support. Their cost and the simplicity of their preparation through N-carboxyanhydride polymerization on beads make them reactants of choice for the formation of disulfide bridges in peptides.
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页码:2382 / 2389
页数:8
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