Oxyfold: A Simple and Efficient Solid-Supported Reagent for Disulfide Bond Formation

被引:10
|
作者
Verdie, Pascal [1 ]
Ronga, Luisa [2 ]
Cristau, Michele [1 ,2 ]
Amblard, Muriel [1 ]
Cantel, Sonia [1 ]
Enjalbal, Christine [1 ]
Puget, Karine [2 ]
Martinez, Jean [1 ]
Subra, Gilles [1 ]
机构
[1] CNRS, IBMM, UMR 5247, F-34000 Montpellier, France
[2] Genepep, Domaine Pins, F-34980 St Clement De Riviere, France
关键词
amino acids; methionine; oxidation; peptides; supported reagents; PHASE PEPTIDE-SYNTHESIS; SOMATOSTATIN; ANALOG;
D O I
10.1002/asia.201100202
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The synthesis and use of novel polymer-supported reagents for disulfide bond formation is described. This family of supported reagents consists of a series of oxidized methionines grafted onto a solid support. Their cost and the simplicity of their preparation through N-carboxyanhydride polymerization on beads make them reactants of choice for the formation of disulfide bridges in peptides.
引用
收藏
页码:2382 / 2389
页数:8
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