Development of a solid-supported biotinylation reagent for efficient biotin labeling of SH groups on small molecules

被引：11

作者：

Fukumoto, Kentarou ^{[1
,2
]}

Adachi, Kumi ^{[1
]}

Kajiyama, Akihiro ^{[1
]}

Yamazaki, Yuri ^{[1
]}

Yakushiji, Fumika ^{[1
]}

Hayashi, Yoshio ^{[1
]}

机构：

[1] Tokyo Univ Pharm & Life Sci, Dept Med Chem, Hachioji, Tokyo 1920392, Japan

[2] Kokusan Chem Co Ltd, Tokyo 1030023, Japan

来源：

TETRAHEDRON LETTERS | 2012年 / 53卷 / 05期

基金：

日本科学技术振兴机构;

关键词：

Solid support; Biotinylation reagent; Npys; Protein modification; SH-specific labeling; RECOMBINANT ANTIBODY MICROARRAYS; CONVERTING-ENZYME; PROTEINS; AVIDIN; PEPTIDES; CYSTEINE; THIOL; ACID; DERIVATIVES; ACTIVATION;

D O I：

10.1016/j.tetlet.2011.11.089

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We report here the design and synthesis of a novel and selective SH-group biotinylating reagent, KSH-1 (1), for the biotinylation of small molecules using solid phase chemistry. The results demonstrate that 1 efficiently biotinylated a small molecule, captopril, and afforded the product in high yield and purity. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：535 / 538

页数：4

共 9 条

[1] A New Solid-supported SR-specific Biotinylation Reagent for the Efficient Biotin-labeling of Small Molecules
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