Oxyfold: A Simple and Efficient Solid-Supported Reagent for Disulfide Bond Formation

被引：10

作者：

Verdie, Pascal ^{[1
]}

Ronga, Luisa ^{[2
]}

Cristau, Michele ^{[1
,2
]}

Amblard, Muriel ^{[1
]}

Cantel, Sonia ^{[1
]}

Enjalbal, Christine ^{[1
]}

Puget, Karine ^{[2
]}

Martinez, Jean ^{[1
]}

Subra, Gilles ^{[1
]}

机构：

[1] CNRS, IBMM, UMR 5247, F-34000 Montpellier, France

[2] Genepep, Domaine Pins, F-34980 St Clement De Riviere, France

来源：

CHEMISTRY-AN ASIAN JOURNAL | 2011年 / 6卷 / 09期

关键词：

amino acids; methionine; oxidation; peptides; supported reagents; PHASE PEPTIDE-SYNTHESIS; SOMATOSTATIN; ANALOG;

D O I：

10.1002/asia.201100202

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The synthesis and use of novel polymer-supported reagents for disulfide bond formation is described. This family of supported reagents consists of a series of oxidized methionines grafted onto a solid support. Their cost and the simplicity of their preparation through N-carboxyanhydride polymerization on beads make them reactants of choice for the formation of disulfide bridges in peptides.

引用

页码：2382 / 2389

页数：8

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