FeCl3-catalyzed alkylation of indoles with 1,3-dicarbonyl compounds:: an expedient synthesis of 3-substituted indoles

被引：33
|
作者：
Yadav, J. S. [1 ]
Reddy, B. V. Subba [1 ]
Praneeth, K. [1 ]
机构：
[1] Indian Inst Chem Technol, Div Organ Chem, Hyderabad 500007, Andhra Pradesh, India
来源：
TETRAHEDRON LETTERS | 2008年 / 49卷 / 01期
关键词：
indoles; iron(III) reagents; 1,3-diketones; C-3; alkylation;
D O I：
10.1016/j.tetlet.2007.09.166
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Indoles undergo smooth alkylation at the 3-position with 1,3-dicarbonyl compounds in the presence of 20 mol % of FeCl3 under mild reaction conditions to produce a wide range of 3-substituted indoles in excellent yields and with high E-selectivity. (c) 2007 Elsevier Ltd. All rights reserved.
引用
收藏
页码：199 / 202
页数：4
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