Improved quantitation for PET/CT image reconstruction with system modeling and anatomical priors

被引：1
|
作者：
Alessio, AM [1 ]
Kinahan, PE [1 ]
Lewellen, TK [1 ]
机构：
[1] Univ Washington, Ctr Med, Imaging Res Lab, Seattle, WA 98195 USA
来源：
MEDICAL IMAGING 2005: IMAGE PROCESSING, PT 1-3 | 2005年 / 5747卷
关键词：
anatomical priors; PSF; segmentation; PET/CT; detector response; fully 3-D PET;
D O I：
10.1117/12.595372
中图分类号：
TB8 [摄影技术];
学科分类号：
0804 ;
摘要：
Accurate quantitation of PET tracer uptake levels in small tumors remains a challenge. This work uses an improved reconstruction algorithm to reduce the quantitative errors due to limited system resolution and due to necessary image noise reduction. We propose a method for finding and using the detection system response in the projection matrix of a statistical reconstruction algorithm. In addition we use aligned anatomical information, available in PET/CT scanners, to govern the penalty term applied during each image update. These improvements are combined with FORE rebinning in a clinically feasible algorithm for reconstructing fully 3D PET data. Simulated results show improved tumor bias and variance characteristics with the new algorithm.
引用
收藏
页码：695 / 703
页数：9
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