TDP-43 shapeshifts to encipher FTD severity

被引：3

作者：

Barbieri, Edward M. ^{[1
]}

Shorter, James ^{[1
]}

机构：

[1] Univ Penn, Dept Biochem & Biophys, Perelman Sch Med, Philadelphia, PA 19104 USA

来源：

NATURE NEUROSCIENCE | 2019年 / 22卷 / 01期

关键词：

RNA-BINDING PROTEINS;

D O I：

10.1038/s41593-018-0299-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

TDP-43 forms cytoplasmic aggregates in degenerating neurons of frontotemporal dementia (FTD) patients. Laferriere et al. now establish that TDP-43 assemblies from distinct FTD subtypes have different structures, neurotoxicities, and seeding activities, which correlate with FTD severity. Thus, distinct pathological TDP-43 assemblies akin to prion strains might underpin distinct FTD subtypes.

引用

页码：3 / 5

页数：3

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