TDP-43 shapeshifts to encipher FTD severity

被引：3
|
作者：
Barbieri, Edward M. [1 ]
Shorter, James [1 ]
机构：
[1] Univ Penn, Dept Biochem & Biophys, Perelman Sch Med, Philadelphia, PA 19104 USA
来源：
NATURE NEUROSCIENCE | 2019年 / 22卷 / 01期
关键词：
RNA-BINDING PROTEINS;
D O I：
10.1038/s41593-018-0299-6
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
TDP-43 forms cytoplasmic aggregates in degenerating neurons of frontotemporal dementia (FTD) patients. Laferriere et al. now establish that TDP-43 assemblies from distinct FTD subtypes have different structures, neurotoxicities, and seeding activities, which correlate with FTD severity. Thus, distinct pathological TDP-43 assemblies akin to prion strains might underpin distinct FTD subtypes.
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收藏
页码：3 / 5
页数：3
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