Novel Multicomponent Domino Approach to 2,5-Bifunctionalized Five-Membered Cyclic Nitrones

被引：5

作者：

Buchlovic, Marian ^{[1
]}

Man, Stanislav ^{[1
]}

Potacek, Milan ^{[1
]}

机构：

[1] Masaryk Univ, Dept Chem, CS-61137 Brno, Czech Republic

来源：

SYNTHESIS-STUTTGART | 2012年 / 44卷 / 06期

关键词：

allenes; alcohols; aldehydes; domino reactions; multicomponent reactions; nitrones; 1,3-DIPOLAR CYCLOADDITION; TANDEM REACTIONS; BUILDING-BLOCKS; TRANSFORMATIONS; UNDERSTAND; RADICALS; STRATEGY; PROTEIN;

D O I：

10.1055/s-0031-1289726

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Multicomponent reactions of 2,2-dimethylpenta- 3,4-dienal oxime with aldehydes and primary alcohols were studied and the optimum conditions for preparing a new family of 2,5-substituted five-membered cyclic nitrones were identified. This reaction offers direct access to the target structures in a single synthetic step. The scope and limitations of the reaction were evaluated, and all products were isolated and fully characterized.

引用

页码：973 / 982

页数：10

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