Novel Multicomponent Domino Approach to 2,5-Bifunctionalized Five-Membered Cyclic Nitrones

被引：5
|
作者：
Buchlovic, Marian [1 ]
Man, Stanislav [1 ]
Potacek, Milan [1 ]
机构：
[1] Masaryk Univ, Dept Chem, CS-61137 Brno, Czech Republic
来源：
SYNTHESIS-STUTTGART | 2012年 / 44卷 / 06期
关键词：
allenes; alcohols; aldehydes; domino reactions; multicomponent reactions; nitrones; 1,3-DIPOLAR CYCLOADDITION; TANDEM REACTIONS; BUILDING-BLOCKS; TRANSFORMATIONS; UNDERSTAND; RADICALS; STRATEGY; PROTEIN;
D O I：
10.1055/s-0031-1289726
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Multicomponent reactions of 2,2-dimethylpenta- 3,4-dienal oxime with aldehydes and primary alcohols were studied and the optimum conditions for preparing a new family of 2,5-substituted five-membered cyclic nitrones were identified. This reaction offers direct access to the target structures in a single synthetic step. The scope and limitations of the reaction were evaluated, and all products were isolated and fully characterized.
引用
收藏
页码：973 / 982
页数：10
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