Epstein-Barr virus-associated T cell lymphoproliferative disorder following autologous blood stem cell transplantation for relapsed Hodgkin's disease

被引:28
|
作者
Yufu, Y
Kimura, M
Kawano, R
Noguchi, Y
Takatsuki, H
Uike, N
Ohshima, K
机构
[1] Kyushu Natl Canc Ctr Hosp, Dept Hematol, Minami Ku, Fukuoka 8111395, Japan
[2] Fukuoka Univ, Sch Med, Dept Pathol 1, Fukuoka 81401, Japan
关键词
post-transplant lymphoproliferative disorder; T cell; Epstein-Barr virus; autologous blood stem cell transplantation;
D O I
10.1038/sj.bmt.1702721
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
Post-transplant lymphoproliferative disorders (PTLD) of T cell type are a rare complication of solid organ and allogeneic hematopoietic cell transplantation (HCT), and usually are not associated with Epstein-Barr virus (EBV) infection. EBV-associatcd T cell PTLD has not been reported to occur after autologous HCT. We report an unusual case of T cell lymphoproliferation after autologous blood stem cell transplantation (ABSCT), A patient with relapsed Hodgkin's disease developed abdominal lymphadenopathy followed by atypical CD8(+) lymphocytosis ill the peripheral blood 30 months following ABSCT, DNA studies of the atypical lymphocytes demonstrated rearrangements of the T cell receptor beta gene and a clonal proliferation of EBV.
引用
收藏
页码:1339 / 1341
页数:3
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