Electrochemical Determination of Dopamine at Nafion and β-Cyclodextrin-Functionalized Multi-Walled Carbon Nanotubes Composite Modified Glassy Carbon Electrode

Dopamine (DA) has been found as a significant neurotransmitter. Since abnormal concentrations of DA can induce a series of serious diseases. Simple, economical and efficient sensors should be developed to detect DA. In this study, a highly selective electrochemical sensor was developed to detect DA using nafion (NA) and multi-walled carbon nanotubes-beta-cyclodextrin (MWCNTs-beta-CD) composite modified glassy carbon electrode (GCE). The MWCNTs-beta-CD composite was prepared by mechanical grinding at ambient temperature, which could be an environment-friendly method. The as-prepared MWCNTs-beta-CD composite was characterized with Scanning electron microscopy and Fourier-transform infrared spectra. Such NA/MWCNTs-beta-CD/GCE based sensor had high performance with a detection ranges from 0.01 to 1 mu M and from 1 to 10 mu M as well as a detection limit of 0.005 mu M. Moreover, the sensor was found with high selectivity, stability, reproducibility and satisfying recovery rate to detect DA in samples. A novel DA sensor was developed with high sensitivity using NA/MWCNTs-beta-CD/GCE, which could be promising to detect DA in pharmaceutical samples.