Protease-Activated Receptor-2 (PAR2) in Human Gastric Mucosa as Mediator of Proinflammatory Effects in Helicobacter pylori Infection

被引：5

作者：

Kandulski, Arne ^{[1
]}

Kuester, Doerthe ^{[2
]}

Moenkemueller, Klaus ^{[1
,3
]}

Fry, Lucia ^{[1
,3
]}

Malfertheiner, Peter ^{[1
]}

Wex, Thomas ^{[1
]}

机构：

[1] Otto Von Guericke Univ, Dept Gastroenterol Hepatol & Infect Dis, D-39120 Magdeburg, Germany

[2] Otto Von Guericke Univ, Inst Pathol, D-39120 Magdeburg, Germany

[3] Marienhosp Bottrop, Dept Internal Med, D-46236 Bottrop, Germany

来源：

HELICOBACTER | 2011年 / 16卷 / 06期

关键词：

Cytokines; inflammation; protease; RT-PCR; LOW-DOSE ASPIRIN; EPITHELIAL-CELLS; INFLAMMATION; INHIBITOR; DISEASE; CANCER; INTERLEUKIN-8; IMMUNITY;

D O I：

10.1111/j.1523-5378.2011.00866.x

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Introduction: Protease-activated receptors (PAR) are seven transmembrane receptors that are expressed throughout the gastrointestinal tract. In vitro experiments using gastric tumor cell lines, murine models and one clinical study provided evidence for a potential role of PAR2 in Helicobacter pylori-induced gastritis.

引用

页码：452 / 458

页数：7

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