Protease-Activated Receptor-2 (PAR2) in Human Gastric Mucosa as Mediator of Proinflammatory Effects in Helicobacter pylori Infection

被引：5
|
作者：
Kandulski, Arne [1 ]
Kuester, Doerthe [2 ]
Moenkemueller, Klaus [1 ,3 ]
Fry, Lucia [1 ,3 ]
Malfertheiner, Peter [1 ]
Wex, Thomas [1 ]
机构：
[1] Otto Von Guericke Univ, Dept Gastroenterol Hepatol & Infect Dis, D-39120 Magdeburg, Germany
[2] Otto Von Guericke Univ, Inst Pathol, D-39120 Magdeburg, Germany
[3] Marienhosp Bottrop, Dept Internal Med, D-46236 Bottrop, Germany
来源：
HELICOBACTER | 2011年 / 16卷 / 06期
关键词：
Cytokines; inflammation; protease; RT-PCR; LOW-DOSE ASPIRIN; EPITHELIAL-CELLS; INFLAMMATION; INHIBITOR; DISEASE; CANCER; INTERLEUKIN-8; IMMUNITY;
D O I：
10.1111/j.1523-5378.2011.00866.x
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Introduction: Protease-activated receptors (PAR) are seven transmembrane receptors that are expressed throughout the gastrointestinal tract. In vitro experiments using gastric tumor cell lines, murine models and one clinical study provided evidence for a potential role of PAR2 in Helicobacter pylori-induced gastritis.
引用
收藏
页码：452 / 458
页数：7
相关论文
共 50 条
  • [21] Protease-activated receptor-2 (PAR-2) as a potential therapeutic target
    Kanke, T
    Takizawa, T
    Kabeya, M
    Kawabata, A
    JOURNAL OF PHARMACOLOGICAL SCIENCES, 2004, 94 : 64P - 64P
  • [22] Differences in protease-activated receptor-2 (PAR2)-mediated vasodilation in a rat model of metabolic syndrome with increasing age
    Maruyama, Kana
    Kagota, Satomi
    Wakuda, Hirokazu
    McGuire, John. J.
    Yoshikawa, Noriko
    Nakamura, Kazuki
    Kunitomo, Masaru
    Shinozuka, Kazumasa
    JOURNAL OF PHARMACOLOGICAL SCIENCES, 2013, 121 : 164P - 164P
  • [23] Development and Evaluation of Small Peptidomimetic Ligands to Protease-Activated Receptor-2 (PAR2) through the Use of Lipid Tethering
    Boitano, Scott
    Hoffman, Justin
    Tillu, Dipti V.
    Asiedu, Marina N.
    Zhang, Zhenyu
    Sherwood, Cara L.
    Wang, Yan
    Dong, Xinzhong
    Price, Theodore J.
    Vagner, Josef
    PLOS ONE, 2014, 9 (06):
  • [24] Modulation of serum IgE by protease-activated receptor-2 (PAR-2).
    Davis, M
    Sigounas, A
    Shibata, Y
    Metzger, WJ
    Henriksen, RA
    FASEB JOURNAL, 1999, 13 (07): : A1472 - A1472
  • [25] The signaling properties and functions of protease-activated receptor (PAR)1 and PAR2 in cardiomyocytes
    Sabri, A
    Andrade-Gordon, P
    Darrow, AL
    Johnson, RW
    Franke, TF
    Steinberg, SF
    CIRCULATION, 1999, 100 (18) : 6 - 6
  • [26] Protease-activated receptor-2 (PAR-2) in cervical cancer proliferation
    Sanchez-Hernandez, Pedro Ernesto
    Ramirez-Duenas, Maria Guadalupe
    Albarran-Somoza, Benibelks
    Garcia-Iglesias, Trinidad
    del Toro-Arreola, Alicia
    Franco-Topete, Ramon
    Daneri-Navarro, Adrian
    GYNECOLOGIC ONCOLOGY, 2008, 108 (01) : 19 - 26
  • [27] Effects of the activated coagulation factor X (FXa) and its protease-activated receptor-2 (PAR2) on colon cancer cell growth in vitro and in vivo
    Meyer, U.
    Polster, S.
    Roennpagel, V.
    Grammbauer, S.
    Dombrowski, F.
    Ritter, C.
    Rauch, B.
    EUROPEAN HEART JOURNAL, 2023, 44
  • [28] A New Strategy in Modulating the Protease-Activated Receptor 2 (Par2) in Autoimmune Diseases
    Khoon, Lynn
    Piran, Ron
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2025, 26 (01)
  • [29] Protease activated receptor 2 (PAR2) is a mediator of nociception in a mouse model of migraine
    Hassler, S.
    Price, T.
    Dussor, G.
    Boitano, S.
    Vagner, J.
    JOURNAL OF PAIN, 2016, 17 (04): : S49 - S49
  • [30] Protease-Activated Receptor 2 (PAR2) Is Upregulated by Acanthamoeba Plasminogen Activator (aPA) and Induces Proinflammatory Cytokine in Human Corneal Epithelial Cells
    Tripathi, Trivendra
    Abdi, Mahshid
    Alizadeh, Hassan
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2014, 55 (06) : 3912 - 3921
12345