Dihydrostilbene glycosides from Camellia sasanqua and their α-glucosidase and α-amylase inhibitory activities

被引：12

作者：

Nguyen Thi Cuc ^{[1
,2
]}

Nguyen The Cuong ^{[3
]}

Luu The Anh ^{[4
]}

Duong Thi Hai Yen ^{[2
]}

Bui Huu Tai ^{[1
,2
]}

Duong Thu Trang ^{[2
]}

Pham Hai Yen ^{[2
]}

Phan Van Kiem ^{[1
,2
]}

Nguyen Hoai Nam ^{[2
]}

Chau Van Minh ^{[2
]}

Nguyen Xuan Nhiem ^{[1
,2
]}

机构：

[1] Grad Univ Sci & Technol, VAST, Hanoi, Vietnam

[2] VAST, Inst Marine Biochem, Hanoi, Vietnam

[3] VAST, Inst Ecol & Biol Resources, Hanoi, Vietnam

[4] Vietnam Natl Univ, Cent Inst Nat Resources & Environm Studies, Hanoi, Vietnam

来源：

NATURAL PRODUCT RESEARCH | 2021年 / 35卷 / 21期

关键词：

Camellia sasanqua; Theaceae; dihydrostilbene; sasastilboside; alpha-glucosidase; alpha-amylase; FLOWER BUDS;

D O I：

10.1080/14786419.2020.1756802

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Using chromatographic methods, three new dihydrostilbene glycosides, sasastilbosides A-C (1-3) and four known compounds, catechin (4), rutin (5), nicotiflorin (6), and rehmaionoside A (7) have been isolated from Camellia sasanqua Thunb. Their chemical structures were elucidated by spectroscopic methods (1 D-, 2 D-NMR) and mass spectra. Compounds 1-7 were evaluated for alpha-glucosidase and alpha-amylase inhibitory effects. Compounds 3 and 4 showed alpha-glucosidase inhibitory activity with IC50 values of 77.6 +/- 1.6 and 72.4 +/- 1.3 mu M, respectively. Compound 1 showed alpha-amylase inhibitory activity with IC50 value of 53.7 +/- 1.6 mu M. [GRAPHICS] .

引用

页码：4025 / 4031

页数：7

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