Dihydrostilbene glycosides from Camellia sasanqua and their α-glucosidase and α-amylase inhibitory activities

被引：12
|
作者：
Nguyen Thi Cuc [1 ,2 ]
Nguyen The Cuong [3 ]
Luu The Anh [4 ]
Duong Thi Hai Yen [2 ]
Bui Huu Tai [1 ,2 ]
Duong Thu Trang [2 ]
Pham Hai Yen [2 ]
Phan Van Kiem [1 ,2 ]
Nguyen Hoai Nam [2 ]
Chau Van Minh [2 ]
Nguyen Xuan Nhiem [1 ,2 ]
机构：
[1] Grad Univ Sci & Technol, VAST, Hanoi, Vietnam
[2] VAST, Inst Marine Biochem, Hanoi, Vietnam
[3] VAST, Inst Ecol & Biol Resources, Hanoi, Vietnam
[4] Vietnam Natl Univ, Cent Inst Nat Resources & Environm Studies, Hanoi, Vietnam
来源：
NATURAL PRODUCT RESEARCH | 2021年 / 35卷 / 21期
关键词：
Camellia sasanqua; Theaceae; dihydrostilbene; sasastilboside; alpha-glucosidase; alpha-amylase; FLOWER BUDS;
D O I：
10.1080/14786419.2020.1756802
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Using chromatographic methods, three new dihydrostilbene glycosides, sasastilbosides A-C (1-3) and four known compounds, catechin (4), rutin (5), nicotiflorin (6), and rehmaionoside A (7) have been isolated from Camellia sasanqua Thunb. Their chemical structures were elucidated by spectroscopic methods (1 D-, 2 D-NMR) and mass spectra. Compounds 1-7 were evaluated for alpha-glucosidase and alpha-amylase inhibitory effects. Compounds 3 and 4 showed alpha-glucosidase inhibitory activity with IC50 values of 77.6 +/- 1.6 and 72.4 +/- 1.3 mu M, respectively. Compound 1 showed alpha-amylase inhibitory activity with IC50 value of 53.7 +/- 1.6 mu M. [GRAPHICS] .
引用
收藏
页码：4025 / 4031
页数：7
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