Synthesis and antituberculosis activity of new fatty acid amides

被引：57

作者：

Montes D'Oca, Caroline Da Ros ^{[1
]}

Coelho, Tatiane ^{[2
]}

Marinho, Tamara Germani ^{[1
]}

Lopes Hack, Carolina Rosa ^{[1
]}

Duarte, Rodrigo da Costa ^{[1
]}

da Silva, Pedro Almeida ^{[2
]}

Montes D'Oca, Marcelo Goncalves ^{[1
]}

机构：

[1] Univ Fed Rio Grande, Escola Quim & Alimentos, Lab Kolbe Sintese Organ, Rio Grande, RS, Brazil

[2] Univ Fed Rio Grande, Fac Med, Lab Micobacteriol, Rio Grande, RS, Brazil

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2010年 / 20卷 / 17期

关键词：

Mycobacterium tuberculosis; Fatty acid amides; Ricinoleic acid; FAMEs; ENDOCANNABINOID SYSTEM; MYCOBACTERIUM-TUBERCULOSIS; ANANDAMIDE; OLEAMIDE; CANCER; TARGET;

D O I：

10.1016/j.bmcl.2010.06.149

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

This work reports the synthesis of new fatty acid amides from C16: 0, 18: 0, 18: 1, 18: 1 (OH), and 18: 2 fatty acids families with cyclic and acyclic amines and demonstrate for the first time the activity of these compounds as antituberculosis agents against Mycobacterium tuberculosis H(37)Rv, M. tuberculosis rifampicin resistance (ATCC 35338), and M. tuberculosis isoniazid resistance (ATCC 35822). The fatty acid amides derivate from ricinoleic acid were the most potent one among a series of tested compounds, with a MIC 6.25 mu g/mL for resistance strains. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：5255 / 5257

页数：3

共 50 条

[41] Synthesis and antituberculosis activity of some phosphorus containing glycolipids on the basis of glucuronic acid
Izmest'ev, Yevgeny
Andreeva, Olga
Sharipova, Radmila
Garifullin, Bulat
Strobykina, Irina
Kravchenko, Marionella
Kataev, Vladimir
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, 2016, 191 (11-12) : 1621 - 1622
[42] SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF BETULONIC ACID AMIDES WITH PIPERAZINE DERIVATIVES
Chue, K-T
Chang, M-S
Ten, L. N.
CHEMISTRY OF NATURAL COMPOUNDS, 2011, 47 (05) : 759 - 763
[43] SYNTHESIS AND PSYCHOTROPIC ACTIVITY OF THE AMIDES OF 2-AMINONICOTINIC ACID
AKHUNDOV, RA
ZHMURENKO, LA
GLOZMAN, OM
VORONINA, TA
ZAGOREVSKY, VA
KHIMIKO-FARMATSEVTICHESKII ZHURNAL, 1986, 20 (01): : 48 - 50
[44] SYNTHESIS AND PHARMACOLOGICAL ACTIVITY OF 3-CARBOXYPICOLINIC ACID AMIDES
Kon'shin, M. E.
Syropyatov, B. Ya.
Vakhrin, M. I.
Neifel'd, P. G.
Feshin, V. P.
Shurov, S. N.
Odegova, T. F.
PHARMACEUTICAL CHEMISTRY JOURNAL, 2010, 44 (09) : 476 - 479
[45] Synthesis and pharmacological activity of amides and the ozonolysis product of maleopimaric acid
Kazakova, O. B.
Tret'yakova, E. V.
Kukovinets, O. S.
Tolstikov, G. A.
Nazyrov, T. I.
Chudov, I. V.
Ismagilova, A. F.
RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY, 2010, 36 (06) : 762 - 770
[46] Synthesis and study of the analgesic and antiinflammatory activity of α-acetoxyphenylacetic acid amides
Mashevskaya I.V.
Vakhrin M.I.
Safin V.A.
D'yakova I.A.
Nikiforova M.A.
Solodnikov S.Y.
Anikina L.V.
Pharmaceutical Chemistry Journal, 2001, 35 (4) : 199 - 200
[47] Synthesis and antibacterial activity of betulonic acid amides with piperazine derivatives
K.-T. Chue
M.-S. Chang
L. N. Ten
Chemistry of Natural Compounds, 2011, 47 : 759 - 763
[48] Synthesis and pharmacological activity of amides and the ozonolysis product of maleopimaric acid
O. B. Kazakova
E. V. Tret’yakova
O. S. Kukovinets
G. A. Tolstikov
T. I. Nazyrov
I. V. Chudov
A. F. Ismagilova
Russian Journal of Bioorganic Chemistry, 2010, 36 : 762 - 770
[49] Synthesis and effect of fatty acid amides as friction modifiers in petroleum base stock
Khalkar, Sharmishtha
Bhowmick, Dipti Narayan
Pratap, Amit
Journal of Oleo Science, 2013, 62 (11): : 901 - 904
[50] Synthesis, Quantification, and Characterization of Fatty Acid Amides from In Vitro and In Vivo Sources
Ni, Ruidong
Bhandari, Suzeeta
Mitchell, Perry R., Jr.
Suarez, Gabriela
Patel, Neel B.
Lamb, Kara
Bisht, Kirpal S.
Merkler, David J.
MOLECULES, 2021, 26 (09):

← 1 2 3 4 5 →