Arginase 2 and Polyamines in Human Pancreatic Beta Cells: Possible Role in the Pathogenesis of Type 2 Diabetes

被引：12
|
作者：
Marselli, Lorella [1 ]
Bosi, Emanuele [1 ]
De Luca, Carmela [1 ]
Del Guerra, Silvia [1 ]
Tesi, Marta [1 ]
Suleiman, Mara [1 ]
Marchetti, Piero [1 ]
机构：
[1] Univ Pisa, Dept Clin & Expt Med, I-56126 Pisa, Italy
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2021年 / 22卷 / 22期
基金：
欧盟地平线“2020”;
关键词：
arginase; 2; polyamines; pancreatic islets; beta cells; type; diabetes; ORNITHINE-DECARBOXYLASE; L-ARGININE; METABOLISM; ISLETS; GENES; LOCALIZATION; DEFICIENCY; SPERMIDINE; TRANSPORT; PATHWAYS;
D O I：
10.3390/ijms222212099
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Arginase 2 (ARG2) is a manganese metalloenzyme involved in several tissue specific processes, from physiology to pathophysiology. It is variably expressed in extra-hepatic tissues and is located in the mitochondria. In human pancreatic beta cells, ARG2 is downregulated in type 2 diabetes. The enzyme regulates the synthesis of polyamines, that are involved in pancreas development and regulation of beta cell function. Here, we discuss several features of ARG2 and polyamines, which can be relevant to the pathophysiology of type 2 diabetes.
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页数：11
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