Arginase 2 and Polyamines in Human Pancreatic Beta Cells: Possible Role in the Pathogenesis of Type 2 Diabetes

被引：12
|
作者：
Marselli, Lorella [1 ]
Bosi, Emanuele [1 ]
De Luca, Carmela [1 ]
Del Guerra, Silvia [1 ]
Tesi, Marta [1 ]
Suleiman, Mara [1 ]
Marchetti, Piero [1 ]
机构：
[1] Univ Pisa, Dept Clin & Expt Med, I-56126 Pisa, Italy
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2021年 / 22卷 / 22期
基金：
欧盟地平线“2020”;
关键词：
arginase; 2; polyamines; pancreatic islets; beta cells; type; diabetes; ORNITHINE-DECARBOXYLASE; L-ARGININE; METABOLISM; ISLETS; GENES; LOCALIZATION; DEFICIENCY; SPERMIDINE; TRANSPORT; PATHWAYS;
D O I：
10.3390/ijms222212099
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Arginase 2 (ARG2) is a manganese metalloenzyme involved in several tissue specific processes, from physiology to pathophysiology. It is variably expressed in extra-hepatic tissues and is located in the mitochondria. In human pancreatic beta cells, ARG2 is downregulated in type 2 diabetes. The enzyme regulates the synthesis of polyamines, that are involved in pancreas development and regulation of beta cell function. Here, we discuss several features of ARG2 and polyamines, which can be relevant to the pathophysiology of type 2 diabetes.
引用
收藏
页数：11
相关论文
共 50 条
  • [31] Type 2 Diabetes and the Aging Pancreatic Beta Cell
    Gunasekaran, Uma
    Gannon, Maureen
    AGING-US, 2011, 3 (06): : 565 - 575
  • [32] Epigenetic dysregulation in pancreatic islets and pathogenesis of type 2 diabetes
    Yokoi, Norihide
    JOURNAL OF DIABETES INVESTIGATION, 2018, 9 (03): : 475 - 477
  • [33] Is Transforming Stem Cells to Pancreatic Beta Cells Still the Holy Grail for Type 2 Diabetes?
    Kahraman, Sevim
    Okawa, Erin R.
    Kulkarni, Rohit N.
    CURRENT DIABETES REPORTS, 2016, 16 (08)
  • [34] Is Transforming Stem Cells to Pancreatic Beta Cells Still the Holy Grail for Type 2 Diabetes?
    Sevim Kahraman
    Erin R. Okawa
    Rohit N. Kulkarni
    Current Diabetes Reports, 2016, 16
  • [35] Pancreatic β cells: Gatekeepers of type 2 diabetes
    Park, Yoo Jin
    Woo, Minna
    JOURNAL OF CELL BIOLOGY, 2019, 218 (04): : 1094 - 1095
  • [36] The role of coffee derivatives in the regulation of pancreatic beta cell function in Type 2 Diabetes
    Sarnsamak, Kittiwadee
    Costabile, Adele
    Hauge-Evans, Astrid
    PROCEEDINGS OF THE NUTRITION SOCIETY, 2020, 79 (OCE2) : E281 - E281
  • [37] Is there a role for the adaptive immune system in pancreatic beta cell failure in type 2 diabetes?
    Westwell-Roper, Clara
    Ehses, Jan A.
    DIABETOLOGIA, 2014, 57 (03) : 447 - 450
  • [38] The role of coffee derivatives in the regulation of pancreatic beta cell function in Type 2 diabetes
    Sarnsamak, K.
    Costabile, A.
    Hauge-Evans, A. C.
    DIABETIC MEDICINE, 2019, 36 : 42 - 43
  • [39] Is there a role for the adaptive immune system in pancreatic beta cell failure in type 2 diabetes?
    Clara Westwell-Roper
    Jan A. Ehses
    Diabetologia, 2014, 57 : 447 - 450
  • [40] The role of Toxoplasma gondii as a possible inflammatory agent in the pathogenesis of type 2 diabetes mellitus in humans
    Molan, Aus
    Nosaka, Kazunori
    Hunter, Michael
    Wang, Wei
    FAMILY MEDICINE AND COMMUNITY HEALTH, 2016, 4 (04): : 44 - 62
12345