behavior;
C57BL/6J;
sample size;
test battery;
129S6/SvEvTac;
D O I:
10.1023/A:1008955016170
中图分类号:
Q5 [生物化学];
学科分类号:
071010 ;
081704 ;
摘要:
Most mixed strain progeny from gene-knockout experiments typically originate from C57BL/6J and one of the 129 substrains, frequently 129S6/SvEvTac. The results of this behavioral survey suggest that C57BL/6J:129S6/SvEvTac mixed strain mice are amenable to behavioral testing. The variability in behavioral tasks for subjects arising from this mixed strain genetic background does not preclude screening with a battery of behavioral tests. With clues provided by a screen of mixed strain subjects, follow-up analyses with isogenic, congenic, or F1 hybrid animals may be targeted to specific behavioral themes.
机构:
LMU Munchen, Fac Vet Med, Chair Anim Nutr & Dietet, Dept Vet Sci, Munich, GermanyLMU Munchen, Fac Vet Med, Chair Anim Nutr & Dietet, Dept Vet Sci, Munich, Germany
Boeswald, Linda F.
Wenderlein, Jasmin
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机构:
LMU Munchen, Fac Vet Med, Inst Infect Dis & Zoonoses, Dept Vet Sci,Chair Bacteriol & Mycol, Munich, GermanyLMU Munchen, Fac Vet Med, Chair Anim Nutr & Dietet, Dept Vet Sci, Munich, Germany
Wenderlein, Jasmin
Siegert, Wolfgang
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Univ Hohenheim, Inst Anim Sci, Stuttgart, GermanyLMU Munchen, Fac Vet Med, Chair Anim Nutr & Dietet, Dept Vet Sci, Munich, Germany
Siegert, Wolfgang
Straubinger, Reinhard K.
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LMU Munchen, Fac Vet Med, Inst Infect Dis & Zoonoses, Dept Vet Sci,Chair Bacteriol & Mycol, Munich, GermanyLMU Munchen, Fac Vet Med, Chair Anim Nutr & Dietet, Dept Vet Sci, Munich, Germany
Straubinger, Reinhard K.
Kienzle, Ellen
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LMU Munchen, Fac Vet Med, Chair Anim Nutr & Dietet, Dept Vet Sci, Munich, GermanyLMU Munchen, Fac Vet Med, Chair Anim Nutr & Dietet, Dept Vet Sci, Munich, Germany
机构:
George Washington Sch Med & Hlth Sci, Childrens Natl Med Ctr, Ctr Mol Physiol Res, Washington, DC USAGeorge Washington Sch Med & Hlth Sci, Childrens Natl Med Ctr, Ctr Mol Physiol Res, Washington, DC USA
Escano, Crisanto S.
Armando, Ines
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George Washington Sch Med & Hlth Sci, Childrens Natl Med Ctr, Ctr Mol Physiol Res, Washington, DC USAGeorge Washington Sch Med & Hlth Sci, Childrens Natl Med Ctr, Ctr Mol Physiol Res, Washington, DC USA
Armando, Ines
Wang, Xiaoyan
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George Washington Sch Med & Hlth Sci, Childrens Natl Med Ctr, Ctr Mol Physiol Res, Washington, DC USAGeorge Washington Sch Med & Hlth Sci, Childrens Natl Med Ctr, Ctr Mol Physiol Res, Washington, DC USA
Wang, Xiaoyan
Asico, Laureano D.
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George Washington Sch Med & Hlth Sci, Childrens Natl Med Ctr, Ctr Mol Physiol Res, Washington, DC USAGeorge Washington Sch Med & Hlth Sci, Childrens Natl Med Ctr, Ctr Mol Physiol Res, Washington, DC USA
Asico, Laureano D.
Pascua, Annabelle
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George Washington Sch Med & Hlth Sci, Childrens Natl Med Ctr, Ctr Mol Physiol Res, Washington, DC USAGeorge Washington Sch Med & Hlth Sci, Childrens Natl Med Ctr, Ctr Mol Physiol Res, Washington, DC USA
Pascua, Annabelle
Yang, Yu
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George Washington Sch Med & Hlth Sci, Childrens Natl Med Ctr, Ctr Mol Physiol Res, Washington, DC USAGeorge Washington Sch Med & Hlth Sci, Childrens Natl Med Ctr, Ctr Mol Physiol Res, Washington, DC USA
Yang, Yu
Wang, Zheng
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George Washington Sch Med & Hlth Sci, Childrens Natl Med Ctr, Ctr Mol Physiol Res, Washington, DC USAGeorge Washington Sch Med & Hlth Sci, Childrens Natl Med Ctr, Ctr Mol Physiol Res, Washington, DC USA
Wang, Zheng
Lau, Yuen-Sum
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机构:
Univ Houston, Dept Pharmacol & Pharmaceut Sci, Houston, TX USAGeorge Washington Sch Med & Hlth Sci, Childrens Natl Med Ctr, Ctr Mol Physiol Res, Washington, DC USA
Lau, Yuen-Sum
Jose, Pedro A.
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George Washington Sch Med & Hlth Sci, Childrens Natl Med Ctr, Ctr Mol Physiol Res, Washington, DC USAGeorge Washington Sch Med & Hlth Sci, Childrens Natl Med Ctr, Ctr Mol Physiol Res, Washington, DC USA