Statistical parameters in behavioral tasks and implications for sample size of C57BL/6J:129S6/SvEvTac mixed strain mice

被引：2
|
作者：
Estill, SJ
Fay, K
Garcia, JA
机构：
[1] Dept Internal Med, Mol Cardiol Div, Dallas, TX 75390 USA
[2] Univ Texas, SW Med Ctr, Dept Biochem, Dallas, TX 75390 USA
来源：
TRANSGENIC RESEARCH | 2001年 / 10卷 / 02期
关键词：
behavior; C57BL/6J; sample size; test battery; 129S6/SvEvTac;
D O I：
10.1023/A:1008955016170
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Most mixed strain progeny from gene-knockout experiments typically originate from C57BL/6J and one of the 129 substrains, frequently 129S6/SvEvTac. The results of this behavioral survey suggest that C57BL/6J:129S6/SvEvTac mixed strain mice are amenable to behavioral testing. The variability in behavioral tasks for subjects arising from this mixed strain genetic background does not preclude screening with a battery of behavioral tests. With clues provided by a screen of mixed strain subjects, follow-up analyses with isogenic, congenic, or F1 hybrid animals may be targeted to specific behavioral themes.
引用
收藏
页码：157 / 175
页数：19
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