Effect of Neoadjuvant and Adjuvant Therapy of Experimental Breast Cancer on the Structure of Mesenteric Lymph Nodes

被引：1
|
作者：
Kazakov, O. V. [1 ]
Kabakov, A. V. [1 ]
Poveshchenko, A. F. [1 ]
Raiter, T. V. [1 ]
Strunkin, D. N. [1 ]
Poveshchenko, O. V. [1 ]
Lykov, A. P. [1 ]
Konenkov, V. I. [1 ]
机构：
[1] Russian Acad Sci, Siberian Div, Fed Res Ctr Cytol & Genet, Affiliated Branch,Res Inst Expt & Clin Lymphol, Novosibirsk, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2018年 / 166卷 / 02期
关键词：
chemically induced breast cancer; female Wistar rats; mesenteric lymph nodes; adjuvant and neoadjuvant chemotherapy; morphometry; LYMPHANGIOGENESIS; THYMUS; MODEL;
D O I：
10.1007/s10517-018-4324-2
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The morphometric analysis of mesenteric lymph nodes was carried out in female Wistar rats with chemically induced breast cancer. In control rats with untreated breast cancer, the volume of the system of sinuses increased in parallel with the appearance of morphological signs of suppression of cell-mediated immunity, inhibition of humoral immunity, and macrophage reaction. Against the background of chemotherapy, we observed a decrease in the volume of paracortex and lymphoid nodules, suppression of proliferative activity of lymphoid cells in paracortical and B-cell zone, and a decrease in macrophage content. After resection of breast cancer followed by chemotherapy course, lymph transport activation, widening of the paracortex, enhanced proliferative activity of cells in the paracortex and B-cell zone, and reduced volumes of lymphoid nodules with and without germinal centers and medullary substance were revealed in comparison with rats subjected neoadjuvant chemotherapy.
引用
收藏
页码：245 / 249
页数：5
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