Effect of Neoadjuvant and Adjuvant Therapy of Experimental Breast Cancer on the Structure of Mesenteric Lymph Nodes

被引：1
|
作者：
Kazakov, O. V. [1 ]
Kabakov, A. V. [1 ]
Poveshchenko, A. F. [1 ]
Raiter, T. V. [1 ]
Strunkin, D. N. [1 ]
Poveshchenko, O. V. [1 ]
Lykov, A. P. [1 ]
Konenkov, V. I. [1 ]
机构：
[1] Russian Acad Sci, Siberian Div, Fed Res Ctr Cytol & Genet, Affiliated Branch,Res Inst Expt & Clin Lymphol, Novosibirsk, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2018年 / 166卷 / 02期
关键词：
chemically induced breast cancer; female Wistar rats; mesenteric lymph nodes; adjuvant and neoadjuvant chemotherapy; morphometry; LYMPHANGIOGENESIS; THYMUS; MODEL;
D O I：
10.1007/s10517-018-4324-2
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The morphometric analysis of mesenteric lymph nodes was carried out in female Wistar rats with chemically induced breast cancer. In control rats with untreated breast cancer, the volume of the system of sinuses increased in parallel with the appearance of morphological signs of suppression of cell-mediated immunity, inhibition of humoral immunity, and macrophage reaction. Against the background of chemotherapy, we observed a decrease in the volume of paracortex and lymphoid nodules, suppression of proliferative activity of lymphoid cells in paracortical and B-cell zone, and a decrease in macrophage content. After resection of breast cancer followed by chemotherapy course, lymph transport activation, widening of the paracortex, enhanced proliferative activity of cells in the paracortex and B-cell zone, and reduced volumes of lymphoid nodules with and without germinal centers and medullary substance were revealed in comparison with rats subjected neoadjuvant chemotherapy.
引用
收藏
页码：245 / 249
页数：5
相关论文
共 50 条
  • [21] Frozen Sections for the Evaluation of Sentinel Lymph Nodes after Neoadjuvant Therapy for Breast Cancer Are Specific but Not Sensitive
    Stehura, M.
    Thompson, C.
    Bomeisl, P.
    Elliott, R.
    Gilmore, H.
    LABORATORY INVESTIGATION, 2014, 94 : 513A - 514A
  • [22] Frozen Sections for the Evaluation of Sentinel Lymph Nodes after Neoadjuvant Therapy for Breast Cancer Are Specific but Not Sensitive
    Stehura, M.
    Thompson, C.
    Bomeisl, P.
    Elliott, R.
    Gilmore, H.
    MODERN PATHOLOGY, 2014, 27 : 513A - 514A
  • [23] Sentinel lymph node and neoadjuvant therapy in breast cancer
    Munoz, M.
    Pahisa, J.
    Xavier Caparros, F.
    Vidal-Sicart, S.
    REVISTA ESPANOLA DE MEDICINA NUCLEAR, 2010, 29 (06): : 319 - 320
  • [24] The effect of neoadjuvant chemoradiation therapy on the prognostic value of lymph nodes after rectal cancer surgery
    Klos, Coen L.
    Shellito, Paul C.
    Rattner, David W.
    Hodin, Richard A.
    Cusack, James C.
    Bordeianou, Liliana
    Sylla, Patricia
    Hong, Theodore S.
    Blaszkowsky, Lawrence
    Ryan, Davis P.
    Lauwers, Gregory Y.
    Chang, Yuchiao
    Berger, David L.
    AMERICAN JOURNAL OF SURGERY, 2010, 200 (04): : 440 - 445
  • [25] Morphology of Pararectal Lymph Nodes in Rectal Cancer after Neoadjuvant Therapy
    Kolotova, N. M.
    Maiborodin, I. V.
    Fursov, S. A.
    Lushnikova, E. L.
    Zarubenkov, O. A.
    Maiborodina, V. I.
    BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 2010, 149 (02) : 250 - 254
  • [26] Morphology of Pararectal Lymph Nodes in Rectal Cancer after Neoadjuvant Therapy
    N. M. Kolotova
    I. V. Maiborodin
    S. A. Fursov
    E. L. Lushnikova
    O. A. Zarubenkov
    V. I. Maiborodina
    Bulletin of Experimental Biology and Medicine, 2010, 149 : 250 - 254
  • [27] The effect of neoadjuvant therapy on the size, number, and distribution of mesorectal lymph nodes
    Yegen, Gulcin
    Keskin, Metin
    Buyuk, Melek
    Kunduz, Enver
    Balik, Emre
    Saglam, Esra Kaytan
    Kapran, Yersu
    Asoglu, Oktar
    Gulluoglu, Mine
    ANNALS OF DIAGNOSTIC PATHOLOGY, 2016, 20 : 29 - 35
  • [28] Level Ill and Interpectoral Lymph Nodes Involvement in Breast Cancer with Positive Axillary Lymph Nodes after Neoadjuvant Chemotherapy
    Fan, Z.
    Li, J.
    Wang, T.
    Xie, Y.
    Fan, T.
    Lin, B.
    Ouyang, T.
    CANCER RESEARCH, 2010, 70
  • [29] Excision of sentinel lymph nodes in breast cancer in the context of neoadjuvant systemic therapy. Aspects on optimization of timing
    Fink, V
    Kuehn, T.
    Janni, W.
    Schwentner, L.
    GYNAKOLOGE, 2014, 47 (08): : 594 - 597
  • [30] ENDOCRINE THERAPY IN BREAST CANCER: THE NEOADJUVANT, ADJUVANT, AND METASTATIC APPROACH
    Reinbolt, Raquel E.
    Mangini, Neha
    Hill, Jordan L.
    Levine, Lauren B.
    Dempsey, Jessica L.
    Singaravelu, Janani
    Koehler, Kevin A.
    Talley, Allison
    Lustberg, Maryam B.
    SEMINARS IN ONCOLOGY NURSING, 2015, 31 (02) : 146 - 155
12345