Population Pharmacokinetics of Labetalol in Hypertensive Patients Using NONMEM

被引:0
|
作者
Kodati, Devender [1 ]
Lingabathula, Harikiran [1 ]
Yellu, Narsimhareddy [1 ]
机构
[1] Kakatiya Univ, Univ Coll Pharmaceut Sci, Dept Pharmacol, Warangal 506009, Telangana, India
来源
LATIN AMERICAN JOURNAL OF PHARMACY | 2016年 / 35卷 / 06期
关键词
hypertension; Indian hypertensive patients; labetalol; NONMEM; population pharmacokinetics; CLINICAL PHARMACOKINETICS; PREGNANCY; DRUGS;
D O I
暂无
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The population pharmacokinetics of labetalol was evaluated based on a mixed-effect model using the NONMEM program. The study was conducted in 58 hypertensive patients, receiving labetalol along with other medications by oral were analyzed according to a two-compartment model in FOCI; method. Labetalol in human plasma was measured by a reverse phase high-performance liquid chromatographic method using UV detection. Additive proportional error model was employed to describe residual and inter-individual variability. The Influence of covariates such as age, gender, bodyweight on to I body clearance, and volume of distribution were examined. Bodyweight showed a significant influence on clearance whereas the volume of distribution was influenced by age. The present population pharmacokinetic model was well described on the individual exposure to labetalol and might have a positive Impact on the management of labetalol therapy in the hypertensive patients.
引用
收藏
页码:1321 / 1326
页数:6
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