A small-molecule agonist of the wnt signaling pathway

被引：102
|
作者：
Liu, J
Wu, X
Mitchell, B
Kintner, C
Ding, S
Schultz, PG
机构：
[1] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA
[2] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA
[3] Salk Inst Biol Studies, San Diego, CA 92186 USA
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 13期
关键词：
cellular adhesion; gene expression; highthroughput; screening; pyrimidines; signal transduction;
D O I：
10.1002/anie.200462552
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
(Chemical Equation Presented) A new tool for developmental biology: A screen of combinatorial chemical libraries identified the 2-amino-4,6- disubstituted pyrimidine 1 as a dose-dependent agonist of Wnt signaling. Tadpoles that developed from embryos treated with 1 had substantial head defects (see right-hand image; left = control). Compound 1 appears to mimic the effects of a Wnt ligand in a Xenopus model and may be a useful tool in the study of physiological processes that involve the Wnt pathway. © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码：1987 / 1990
页数：4
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