A small-molecule agonist of the wnt signaling pathway

被引：102

作者：

Liu, J

Wu, X

Mitchell, B

Kintner, C

Ding, S

Schultz, PG

机构：

[1] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA

[2] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA

[3] Salk Inst Biol Studies, San Diego, CA 92186 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 13期

关键词：

cellular adhesion; gene expression; highthroughput; screening; pyrimidines; signal transduction;

D O I：

10.1002/anie.200462552

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) A new tool for developmental biology: A screen of combinatorial chemical libraries identified the 2-amino-4,6- disubstituted pyrimidine 1 as a dose-dependent agonist of Wnt signaling. Tadpoles that developed from embryos treated with 1 had substantial head defects (see right-hand image; left = control). Compound 1 appears to mimic the effects of a Wnt ligand in a Xenopus model and may be a useful tool in the study of physiological processes that involve the Wnt pathway. © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：1987 / 1990

页数：4

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