A small-molecule agonist of the wnt signaling pathway

被引：102
|
作者：
Liu, J
Wu, X
Mitchell, B
Kintner, C
Ding, S
Schultz, PG
机构：
[1] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA
[2] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA
[3] Salk Inst Biol Studies, San Diego, CA 92186 USA
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 13期
关键词：
cellular adhesion; gene expression; highthroughput; screening; pyrimidines; signal transduction;
D O I：
10.1002/anie.200462552
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
(Chemical Equation Presented) A new tool for developmental biology: A screen of combinatorial chemical libraries identified the 2-amino-4,6- disubstituted pyrimidine 1 as a dose-dependent agonist of Wnt signaling. Tadpoles that developed from embryos treated with 1 had substantial head defects (see right-hand image; left = control). Compound 1 appears to mimic the effects of a Wnt ligand in a Xenopus model and may be a useful tool in the study of physiological processes that involve the Wnt pathway. © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码：1987 / 1990
页数：4
相关论文
共 50 条
  • [1] Small-molecule synergist of the Wnt/β-catenin signaling pathway
    Zhang, Qisheng
    Major, Michael B.
    Takanashi, Shinichi
    Camp, Nathan D.
    Nishiya, Naoyuki
    Peters, Eric C.
    Ginsberg, Mark H.
    Schultz, Peter G.
    Moon, Randall T.
    Ding, Sheng
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (18) : 7444 - 7448
  • [2] Development of a small-molecule inhibitor targeting the Wnt signaling pathway.
    Yamada, Tesshi
    Masuda, Mari
    Sawa, Masaaki
    MOLECULAR CANCER THERAPEUTICS, 2013, 12 (11)
  • [3] Targeting Wnt signaling pathway with small-molecule therapeutics for treating osteoporosis
    Ahamad, Shakir
    Saquib, Mohammad
    Hussain, Mohd Kamil
    Bhat, Shahnawaz Ali
    BIOORGANIC CHEMISTRY, 2025, 156
  • [4] Small-molecule inhibitors of Wnt signaling pathway: towards novel anticancer therapeutics
    Zheng, Shilong
    Liu, Jiawang
    Wu, Yanyuan
    Huang, Tien L.
    Wang, Guangdi
    FUTURE MEDICINAL CHEMISTRY, 2015, 7 (18) : 2485 - 2505
  • [5] Small-Molecule Inhibitors Targeting the Canonical WNT Signaling Pathway for the Treatment of Cancer
    Liu, Zhiqing
    Wang, Pingyuan
    Wold, Eric A.
    Song, Qiaoling
    Zhao, Chenyang
    Wang, Changyun
    Zhou, Jia
    JOURNAL OF MEDICINAL CHEMISTRY, 2021, 64 (08) : 4257 - 4288
  • [6] Small-molecule modulators of Hh and Wnt signaling pathways
    Kiselyov, Alex S.
    Tkachenko, Sergey E.
    Balakin, Konstantin V.
    Ivachtchenko, Alexandre V.
    EXPERT OPINION ON THERAPEUTIC TARGETS, 2007, 11 (08) : 1087 - 1101
  • [7] A small-molecule antagonist of the hedgehog signaling pathway
    Lee, Jongkook
    Wu, Xu
    di Magliano, Marina Pasca
    Peters, Eric C.
    Wang, Yan
    Hong, Jiyong
    Hebrok, Metthias
    Din, Sheng
    Cho, Charles Y.
    Schultz, Peter G.
    CHEMBIOCHEM, 2007, 8 (16) : 1916 - +
  • [8] Small-molecule synergist of the Wnt/β-catenin signaling pathway (vol 104, pg 7444, 2007)
    Zhang, Qisheng
    Major, Michael B.
    Takanashi, Shinichi
    Camp, Nathan D.
    Nishiya, Naoyuki
    Peters, Eric C.
    Ginsberg, Mark H.
    Jian, Xiaoying
    Randazzo, Paul A.
    Schultz, Peter G.
    Moon, Randall T.
    Ding, Sheng
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (30) : 12581 - 12581
  • [9] Recent Advances in Wnt/β-Catenin Pathway Small-Molecule Inhibitors
    Holsworth, Daniel D.
    Krauss, Stefan
    ANNUAL REPORTS IN MEDICINAL CHEMISTRY, VOL 47, 2012, 47 : 393 - 409
  • [10] Small-molecule modulators of the Sonic Hedgehog signaling pathway
    Stanton, Benjamin Z.
    Peng, Lee F.
    MOLECULAR BIOSYSTEMS, 2010, 6 (01) : 44 - 54
12345