Synthesis and Primary Antitumor Screening of 5-Ylidene Derivatives of 3-(Morpholin-4-yl)-2-sulfanylidene-1,3-thiazolidin-4-one

被引：11
|
作者：
Horishny, V. Ya. [1 ]
Chaban, T. I. [1 ]
Matiychuk, V. S. [2 ]
机构：
[1] Danila Halytsky Lviv Natl Med Univ, UA-79010 Lvov, Ukraine
[2] Ivan Franko Lviv Natl Univ, UA-79005 Lvov, Ukraine
来源：
RUSSIAN JOURNAL OF ORGANIC CHEMISTRY | 2020年 / 56卷 / 03期
关键词：
3-morpholinorhodanine; 5-ylidene-3-(morpholin-4-yl)-2-sulfanylidene-1; 3-thiazolidin-4-ones; antitumor activity; DRUG; RHODANINE; SCAFFOLD;
D O I：
10.1134/S1070428020030148
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A preparative procedure has been developed for the synthesis of 3-(morpholin-4-yl)-2-sulfanylidene-1,3-thiazolidin-4-one (3-morpholinorhodanine). Its reaction with aldehydes afforded a number of previously unknown 5-ylidene derivatives which were screened for antitumor activity. The synthesized compounds showed a moderate activity against most malignant tumor cells. The renal cancer cell lines UO31 and TK10 were found to be most sensitive to all the tested compounds.
引用
收藏
页码：454 / 457
页数：4
相关论文
共 50 条
  • [31] 2-(4-Bromophenyl)-3-(4-hydroxyphenyl)-1,3-thiazolidin-4-one
    Vennila, Jasmine P.
    Thiruvadigal, D. John
    Kavitha, Helen P.
    Chakkaravarthi, G.
    Manivannan, V.
    ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2011, 67 : O1902 - U1796
  • [32] 3-Cyclohexyl-2-thioxo-1,3-thiazolidin-4-one
    Shahwar, Durre
    Tahir, M. Nawaz
    Yasmeen, Asma
    Ahmad, Naeem
    Khan, Muhammad Akmal
    ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2009, 65 : O3015 - U2168
  • [33] 3-[5-(4-fluorophenyl)-1,3,4-thiadiazol-2-yl]-2-(4-methoxyphenyl)-1,3-thiazolidin-4-one
    Yin, Li-He
    Wan, Rong
    Han, Feng
    Wang, Bin
    Wang, Jin-Tang
    ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2008, 64 : O1359 - U2756
  • [34] 3-Benzyl-2-(furan-2-yl)-1,3-thiazolidin-4-one
    Fun, Hoong-Kun
    Hemamalini, Madhukar
    Shanmugavelan, Poovan
    Ponnuswamy, Alagusundaram
    Jagatheesan, Rathinavel
    ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2011, 67 : O2807 - +
  • [35] 2-(4-Fluorophenyl)-3-[5-(4-nitrophenyl)-1,3,4-thiadiazol-2-yl]-1,3-thiazolidin-4-one
    Yu, Peng
    An, Kang
    He, Qiu
    Zhang, Jian-Qaing
    Wan, Rong
    ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2010, 66 : O1737 - U869
  • [36] 5-Benzylidene-3-phenyl-2-phenylimino-1,3-thiazolidin-4-one
    Zeller, Matthias
    Satam, Vijay
    Bandi, Ravi Kumar
    Behera, Ajaya Kumar
    Mishra, Bijay Kumar
    Pati, Hari
    Lee, Moses
    ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2011, 67 : O1781 - U1483
  • [37] 3-Benzyl-2-phenyl-1,3-thiazolidin-4-one
    Fun, Hoong-Kun
    Hemamalini, Madhukar
    Shanmugavelan, Poovan
    Ponnuswamy, Alagusundaram
    Jagatheesan, Rathinavel
    ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2011, 67 : O2706 - +
  • [38] 3-phenyl-2-thioxo-1,3-thiazolidin-4-one
    Zhu, Feng-Xia
    Zhou, Jian-Feng
    Gong, Gui-Xia
    ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2008, 64 : O1998 - U4433
  • [39] Variable intermolecular interactions in 2-aryl-3-(pyridin-2-yl)-1,3-thiazolidin-4-one derivatives
    Gouvea, Daniela Pires
    Bosenbecker, Juliano
    Cunico, Wilson
    Wardell, Solange M. S. V.
    Wardell, James L.
    ZEITSCHRIFT FUR KRISTALLOGRAPHIE-CRYSTALLINE MATERIALS, 2013, 228 (08): : 382 - 393
  • [40] 3-(Prop-2-en-1-yl)-2-sulfanylidene-1,2,3,4-tetrahydroquinazolin-4-one
    Al-Salahi, Rashad
    Al-Omar, Mohamed
    Marzouk, Mohamed
    Ng, Seik Weng
    ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS, 2012, 68 : O1810 - +
12345