Synthesis and Primary Antitumor Screening of 5-Ylidene Derivatives of 3-(Morpholin-4-yl)-2-sulfanylidene-1,3-thiazolidin-4-one

被引：11
|
作者：
Horishny, V. Ya. [1 ]
Chaban, T. I. [1 ]
Matiychuk, V. S. [2 ]
机构：
[1] Danila Halytsky Lviv Natl Med Univ, UA-79010 Lvov, Ukraine
[2] Ivan Franko Lviv Natl Univ, UA-79005 Lvov, Ukraine
来源：
RUSSIAN JOURNAL OF ORGANIC CHEMISTRY | 2020年 / 56卷 / 03期
关键词：
3-morpholinorhodanine; 5-ylidene-3-(morpholin-4-yl)-2-sulfanylidene-1; 3-thiazolidin-4-ones; antitumor activity; DRUG; RHODANINE; SCAFFOLD;
D O I：
10.1134/S1070428020030148
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A preparative procedure has been developed for the synthesis of 3-(morpholin-4-yl)-2-sulfanylidene-1,3-thiazolidin-4-one (3-morpholinorhodanine). Its reaction with aldehydes afforded a number of previously unknown 5-ylidene derivatives which were screened for antitumor activity. The synthesized compounds showed a moderate activity against most malignant tumor cells. The renal cancer cell lines UO31 and TK10 were found to be most sensitive to all the tested compounds.
引用
收藏
页码：454 / 457
页数：4
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