Copper-catalyzed coupling of hydroxylamines with aryl iodides

被引：51
|
作者：
Jones, Kerri L. [1 ]
Porzelle, Achim [1 ]
Hall, Adrian [2 ]
Woodrow, Michael D. [3 ]
Tomkinson, Nicholas C. O. [1 ]
机构：
[1] Cardiff Univ, Sch Chem, Cardiff CF10 3AT, S Glam, Wales
[2] GlaxoSmithKline, Harlow CM19 5AW, Essex, England
[3] GlaxoSmithKline, Stevenage SG1 2NY, Herts, England
来源：
ORGANIC LETTERS | 2008年 / 10卷 / 05期
基金：
英国工程与自然科学研究理事会;
关键词：
D O I：
10.1021/ol7029273
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient method for the copper-catalyzed N-arylation of hydroxylamines with aryl iodides is described. A variety of M and O-functionalized hydroxylamines were transformed in good to excellent yield with a broad range of aryl coupling partners. Methods for the selective deprotection of either the N- or O-substituents for further functionalization are also described.
引用
收藏
页码：797 / 800
页数：4
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