Dual-targeting RNA nanoparticles for efficient delivery of polymeric siRNA to cancer cells

被引：21
|
作者：
Kim, Taehyung [1 ]
Hyun, Hana [1 ]
Heo, Roun [2 ]
Nam, Keonwook [1 ]
Yang, Kyungjik [1 ]
Kim, Young Min [1 ]
Lee, Yoon Suk [1 ]
An, Jae Yoon [3 ]
Park, Jae Hyung [2 ,3 ]
Choi, Ki Young [4 ]
Roh, Young Hoon [1 ]
机构：
[1] Yonsei Univ, Coll Life Sci & Biotechnol, Dept Biotechnol, 50 Yonsei Ro, Seoul 03722, South Korea
[2] Sungkyunkwan Univ, Dept Hlth Sci & Technol, SAIHST, 2066 Seobu Ro, Suwon 16419, South Korea
[3] Sungkyunkwan Univ, Sch Chem Engn, 2066 Seobu Ro, Suwon 16419, South Korea
[4] Korea Inst Sci & Technol, Nat Prod Informat Res Ctr, 679 Saimdang Ro, Gangneung Si 25451, Gangwon Do, South Korea
来源：
CHEMICAL COMMUNICATIONS | 2020年 / 56卷 / 49期
基金：
新加坡国家研究基金会;
关键词：
PROGRESS REPORT; IN-VITRO; MICROSPONGES; INTERFERENCE; NANOCARRIERS; CHALLENGES; DISEASE;
D O I：
10.1039/d0cc01848a
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A new dual-targeting polymeric siRNA nanoparticle (Dual-PSNP) was developed via multiple processes: rolling circle transcription, condensation, electrostatic deposition, and click chemistry. The Dual-PSNP showed significantly improved cancer-specific intracellular delivery, gene knockdown efficacy, and apoptosis-mediated cytotoxicity through additive receptor-mediated interactions of the two ligands.
引用
收藏
页码：6624 / 6627
页数：4
相关论文
共 50 条
  • [41] Conjugate for efficient delivery of short interfering RNA (siRNA) into mammalian cells
    Muratovska, A
    Eccles, MR
    FEBS LETTERS, 2004, 558 (1-3) : 63 - 68
  • [42] A dual-targeting DNA tetrahedron nanocarrier for breast cancer cell imaging and drug delivery
    Liu, Xiaoting
    Wu, Lina
    Wang, Lei
    Jiang, Wei
    TALANTA, 2018, 179 : 356 - 363
  • [43] Confocal Microscopy for the Analysis of siRNA Delivery by Polymeric Nanoparticles
    Portis, Amanda M.
    Carballo, Georgina
    Baker, Gregory L.
    Chan, Christina
    Walton, S. Patrick
    MICROSCOPY RESEARCH AND TECHNIQUE, 2010, 73 (09) : 878 - 885
  • [44] Phenylboronic Acid-Functionalized Micelles Dual-Targeting Boronic Acid Transporter and Polysaccharides for siRNA Delivery into Brown Algae
    Yoshinaga, Naoto
    Miyamoto, Takaaki
    Goto, Mami
    Tanaka, Atsuko
    Numata, Keiji
    JACS AU, 2024, 4 (04): : 1385 - 1395
  • [45] A Novel Therapeutic siRNA Nanoparticle Designed for Dual-Targeting CD44 and Gli1 of Gastric Cancer Stem Cells
    Yao, Hongjuan
    Sun, Lan
    Li, Jingcao
    Zhou, Xiaofei
    Li, Rui
    Shao, Rongguang
    Zhang, Yingge
    Li, Liang
    INTERNATIONAL JOURNAL OF NANOMEDICINE, 2020, 15 : 7013 - 7034
  • [46] Reduction/photo dual-responsive polymeric prodrug nanoparticles for programmed siRNA and doxorubicin delivery
    Wu, Ming
    Li, Jiong
    Lin, Xinyi
    Wei, Zuwu
    Zhang, Da
    Zhao, Bixing
    Liu, Xiaolong
    Liu, Jingfeng
    BIOMATERIALS SCIENCE, 2018, 6 (06) : 1457 - 1468
  • [47] Polymeric liposomes targeting dual transporters for highly efficient oral delivery of paclitaxel
    Xing, Yabing
    Lian, Xinjie
    Zhang, Yuru
    Zhang, Yulu
    Guo, Xinhong
    CARBOHYDRATE POLYMERS, 2024, 334
  • [48] Ionizable polymeric micelles (IPMs) for efficient siRNA delivery
    Zhou, Ziyu
    Feng, Yu
    Jiang, Mingzhou
    Yao, Zijun
    Wang, Jing
    Pan, Feng
    Feng, Rulan
    Zhao, Chong
    Ma, Yinyu
    Zhou, Jinge
    Sun, Lei
    Sun, Xiaotian
    Zhan, Changyou
    He, Xiao
    Jiang, Kuan
    Yu, Jiahui
    Yan, Zhiqiang
    NATURE COMMUNICATIONS, 2025, 16 (01)
  • [49] Target peptide conjugate promoting efficient delivery of short interfering RNA (siRNA) into cervical cancer cells
    Liu, W. L.
    Stevenson, M.
    Seymour, L. W.
    HUMAN GENE THERAPY, 2008, 19 (04) : 403 - 403
  • [50] Environmentally Responsive Dual-Targeting Nanoparticles: Improving Drug Accumulation in Cancer Cells as a Way of Preventing Anticancer Drug Efflux
    Daglioglu, Cenk
    JOURNAL OF PHARMACEUTICAL SCIENCES, 2018, 107 (03) : 934 - 941
12345