Dual-targeting RNA nanoparticles for efficient delivery of polymeric siRNA to cancer cells

被引：21

作者：

Kim, Taehyung ^{[1
]}

Hyun, Hana ^{[1
]}

Heo, Roun ^{[2
]}

Nam, Keonwook ^{[1
]}

Yang, Kyungjik ^{[1
]}

Kim, Young Min ^{[1
]}

Lee, Yoon Suk ^{[1
]}

An, Jae Yoon ^{[3
]}

Park, Jae Hyung ^{[2
,3
]}

Choi, Ki Young ^{[4
]}

Roh, Young Hoon ^{[1
]}

机构：

[1] Yonsei Univ, Coll Life Sci & Biotechnol, Dept Biotechnol, 50 Yonsei Ro, Seoul 03722, South Korea

[2] Sungkyunkwan Univ, Dept Hlth Sci & Technol, SAIHST, 2066 Seobu Ro, Suwon 16419, South Korea

[3] Sungkyunkwan Univ, Sch Chem Engn, 2066 Seobu Ro, Suwon 16419, South Korea

[4] Korea Inst Sci & Technol, Nat Prod Informat Res Ctr, 679 Saimdang Ro, Gangneung Si 25451, Gangwon Do, South Korea

来源：

CHEMICAL COMMUNICATIONS | 2020年 / 56卷 / 49期

基金：

新加坡国家研究基金会;

关键词：

PROGRESS REPORT; IN-VITRO; MICROSPONGES; INTERFERENCE; NANOCARRIERS; CHALLENGES; DISEASE;

D O I：

10.1039/d0cc01848a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new dual-targeting polymeric siRNA nanoparticle (Dual-PSNP) was developed via multiple processes: rolling circle transcription, condensation, electrostatic deposition, and click chemistry. The Dual-PSNP showed significantly improved cancer-specific intracellular delivery, gene knockdown efficacy, and apoptosis-mediated cytotoxicity through additive receptor-mediated interactions of the two ligands.

引用

页码：6624 / 6627

页数：4

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