Dual-targeting RNA nanoparticles for efficient delivery of polymeric siRNA to cancer cells

被引：21
|
作者：
Kim, Taehyung [1 ]
Hyun, Hana [1 ]
Heo, Roun [2 ]
Nam, Keonwook [1 ]
Yang, Kyungjik [1 ]
Kim, Young Min [1 ]
Lee, Yoon Suk [1 ]
An, Jae Yoon [3 ]
Park, Jae Hyung [2 ,3 ]
Choi, Ki Young [4 ]
Roh, Young Hoon [1 ]
机构：
[1] Yonsei Univ, Coll Life Sci & Biotechnol, Dept Biotechnol, 50 Yonsei Ro, Seoul 03722, South Korea
[2] Sungkyunkwan Univ, Dept Hlth Sci & Technol, SAIHST, 2066 Seobu Ro, Suwon 16419, South Korea
[3] Sungkyunkwan Univ, Sch Chem Engn, 2066 Seobu Ro, Suwon 16419, South Korea
[4] Korea Inst Sci & Technol, Nat Prod Informat Res Ctr, 679 Saimdang Ro, Gangneung Si 25451, Gangwon Do, South Korea
来源：
CHEMICAL COMMUNICATIONS | 2020年 / 56卷 / 49期
基金：
新加坡国家研究基金会;
关键词：
PROGRESS REPORT; IN-VITRO; MICROSPONGES; INTERFERENCE; NANOCARRIERS; CHALLENGES; DISEASE;
D O I：
10.1039/d0cc01848a
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A new dual-targeting polymeric siRNA nanoparticle (Dual-PSNP) was developed via multiple processes: rolling circle transcription, condensation, electrostatic deposition, and click chemistry. The Dual-PSNP showed significantly improved cancer-specific intracellular delivery, gene knockdown efficacy, and apoptosis-mediated cytotoxicity through additive receptor-mediated interactions of the two ligands.
引用
收藏
页码：6624 / 6627
页数：4
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