New pregnane saponins from Ecdysanthera rosea and their cytotoxicity

被引：12
|
作者：
Zhu, Xiangdong [1 ,2 ]
Wu, Guisheng [1 ]
Xiang, Jianying [3 ]
Luo, Huairong [1 ]
Luo, Shide [1 ]
Zhu, Hongmei [4 ]
Wang, Yifen [1 ]
机构：
[1] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Yunnan, Peoples R China
[2] Jiangxi Agr Univ, Coll Biosci & Bioengn, Nanchang 330045, Peoples R China
[3] Chinese Acad Sci, Key Lab Biodivers & Biogeog, Kunming Inst Bot, Kunming 650204, Yunnan, Peoples R China
[4] Xiamen Univ, Coll Oceanog & Environm Sci, Xiamen 361000, Peoples R China
来源：
FITOTERAPIA | 2011年 / 82卷 / 04期
关键词：
Ecdysanthera rosea; Pregnane saponin; Ecdysantheroside B; Cytotoxicity; GLYCOSIDES; TRITERPENE;
D O I：
10.1016/j.fitote.2011.01.022
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Two new pregnane saponins elucidated as ecdysantheroside A (1) and ecdysantheroside B (2) and six known compounds (3-8) based on spectral data (MS, IR, 1D and 2D NMR) were isolated from the stem bark of Ecdysanthera rosea. The cytotoxicity against six cell lines of these compounds was tested by MTT assay. The results revealed that compounds 5 and 7 showed cytotoxicity against all the cell lines. Compound 2 showed cytotoxicity against cells A549, MDA435, HepG2, and HUVEC, while compound 4 showed cytotoxicity against cells A549, CEM, and HUVEC. Compound 6 had cytotoxicity against the others except cell HepG2. (C) 2011 Elsevier B.V. All rights reserved.
引用
收藏
页码：632 / 636
页数：5
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