New pregnane saponins from Ecdysanthera rosea and their cytotoxicity

被引：12
|
作者：
Zhu, Xiangdong [1 ,2 ]
Wu, Guisheng [1 ]
Xiang, Jianying [3 ]
Luo, Huairong [1 ]
Luo, Shide [1 ]
Zhu, Hongmei [4 ]
Wang, Yifen [1 ]
机构：
[1] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Yunnan, Peoples R China
[2] Jiangxi Agr Univ, Coll Biosci & Bioengn, Nanchang 330045, Peoples R China
[3] Chinese Acad Sci, Key Lab Biodivers & Biogeog, Kunming Inst Bot, Kunming 650204, Yunnan, Peoples R China
[4] Xiamen Univ, Coll Oceanog & Environm Sci, Xiamen 361000, Peoples R China
来源：
FITOTERAPIA | 2011年 / 82卷 / 04期
关键词：
Ecdysanthera rosea; Pregnane saponin; Ecdysantheroside B; Cytotoxicity; GLYCOSIDES; TRITERPENE;
D O I：
10.1016/j.fitote.2011.01.022
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Two new pregnane saponins elucidated as ecdysantheroside A (1) and ecdysantheroside B (2) and six known compounds (3-8) based on spectral data (MS, IR, 1D and 2D NMR) were isolated from the stem bark of Ecdysanthera rosea. The cytotoxicity against six cell lines of these compounds was tested by MTT assay. The results revealed that compounds 5 and 7 showed cytotoxicity against all the cell lines. Compound 2 showed cytotoxicity against cells A549, MDA435, HepG2, and HUVEC, while compound 4 showed cytotoxicity against cells A549, CEM, and HUVEC. Compound 6 had cytotoxicity against the others except cell HepG2. (C) 2011 Elsevier B.V. All rights reserved.
引用
收藏
页码：632 / 636
页数：5
相关论文
共 50 条
  • [21] CONVERSION OF STEROID SAPONINS TO CORRESPONDING PREGNANE GLYCOSIDES
    MIYAHARA, K
    KAWASAKI, T
    IDA, Y
    CHEMICAL & PHARMACEUTICAL BULLETIN, 1972, 20 (11) : 2506 - +
  • [22] Identification and Cytotoxic Evaluation of Pregnane Saponins from the Twigs and Leaves of Dregea volubilis
    Vu, Thi Diep
    Nguyen, Manh Khoa
    Nguyen, Thi Thu
    Tran, Thi Hien
    Nguyen, Hoang Tuan
    Do, Thi Ha
    CHEMISTRY & BIODIVERSITY, 2024, 21 (01)
  • [23] A pair of isomeric saponins with cytotoxicity from Albizzia julibrissin
    Zou, K
    Cui, JR
    Wang, B
    Zhao, YY
    Zhang, RY
    JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2005, 7 (06) : 783 - 789
  • [24] Cytotoxicity of pregnane glycosides of Cynanchum otophyllum
    Zhang, Mi
    Li, Xiang
    Xiang, Cheng
    Qin, Yi
    He, Jing
    Li, Bao-Cai
    Li, Peng
    STEROIDS, 2015, 104 : 49 - 60
  • [25] Three new dammarane-type triterpenoid saponins and their cytotoxicity from steamed Panax notoginseng
    Yao, Yi -Fei
    Ni, Wei
    Zhou, Yong-Sheng
    Yan, Huan
    Liu, Hai -Yang
    PHYTOCHEMISTRY LETTERS, 2024, 62 : 1 - 5
  • [26] Immunomodulatory proanthocyanidins from Ecdysanthera utilis
    Lin, LC
    Kuo, YC
    Chou, CJ
    JOURNAL OF NATURAL PRODUCTS, 2002, 65 (04): : 505 - 508
  • [27] Aspidsaponins A-D, Four new steroidal saponins from the rhizomes of Aspidistra elatior Blume and their cytotoxicity
    Zuo, Sheng-Qi
    Liu, Ying-Nan
    Yang, Yang
    Guo, Zhi-Qiang
    Liu, Cheng-Xiong
    Guo, Zhi-Yong
    He, Hai-Bo
    Tu, Xuan
    Zou, Kun
    PHYTOCHEMISTRY LETTERS, 2018, 25 : 126 - 131
  • [28] Six new dammarane-type triterpene saponins from Panax ginseng flower buds and their cytotoxicity
    Li, Ke-Ke
    Li, Sha-Sha
    Xu, Fei
    Gong, Xiao-Jie
    JOURNAL OF GINSENG RESEARCH, 2020, 44 (02) : 215 - 221
  • [29] Tareciliosides N–S: further cycloartane saponins from the leaves of Tarenna gracilipes, and cytotoxicity of saponins and triterpenes
    Zhimin Zhao
    Katsuyoshi Matsunami
    Hideaki Otsuka
    Takakazu Shinzato
    Yoshio Takeda
    Journal of Natural Medicines, 2013, 67 : 503 - 511
  • [30] New pregnane steroids from Turraea pubescens
    Wang, Xiao-Ning
    Fan, Cheng-Qi
    Yue, Jian-Min
    STEROIDS, 2006, 71 (08) : 720 - 724
12345