Combinatorial Targeting of Leukemia and Stromal Cells Overcomes Fms-like Tyrosine Kinase 3 (FLT3) Inhibitor Resistance in Acute Myeloid Leukemia (AML)

被引：0
|
作者：
Bhattacharya, Seemana [1 ,2 ]
Mu, Hong [1 ,2 ]
Piya, Sujan [1 ,2 ]
Zhang, Weiguo [1 ,2 ]
McQueen, Teresa [1 ,2 ]
Paradiso, Linda [3 ]
Oberkovitz, Galia [4 ]
Benami, Eyal [4 ]
Andreeff, Michael [1 ,2 ]
Borthakur, Gautam [1 ,2 ]
机构：
[1] Univ Texas MD Anderson Canc Ctr, Dept Leukemia, Houston, TX 77030 USA
[2] Univ Texas MD Anderson Canc Ctr, Sect Mol Hematol & Therapy, Houston, TX 77030 USA
[3] Strategia Therapeut Inc, 28420 Hardy Toll Rd,Suite 110, Spring, TX USA
[4] BioLineRx Ltd, Modiin Technol Pk 2,HaMaayan St, Modiin, Israel
来源：
CLINICAL LYMPHOMA MYELOMA & LEUKEMIA | 2017年 / 17卷
关键词：
AML; FLT3-ITD; dual MEK1-FLT3 inhibitor; peptidic CXCR4-antagonist; leukemia-stroma interactions;
D O I：
10.1016/j.clml.2017.07.049
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
AML-033
引用
收藏
页码：S273 / S273
页数：1
相关论文
共 50 条
  • [41] Targeting FLT3 Mutations in Acute Myeloid Leukemia
    El Fakih, Riad
    Rasheed, Walid
    Hawsawi, Yousef
    Alsermani, Maamoun
    Hassanein, Mona
    CELLS, 2018, 7 (01)
  • [42] How acute myeloid leukemia (AML) escapes from FMS-related tyrosine kinase 3 (FLT3) inhibitors? Still an overrated complication?
    Perrone, Salvatore
    Ottone, Tiziana
    Zhdanovskaya, Nadezda
    Molica, Matteo
    CANCER DRUG RESISTANCE, 2023, 6 (02) : 223 - 238
  • [43] Targeting integrin linked kinase and FMS-like tyrosine kinase-3 is cytotoxic to acute myeloid leukemia stem cells but spares normal progenitors
    Muranyi, Andrew L.
    Dedhar, Shoukat
    Hogge, Donna E.
    LEUKEMIA RESEARCH, 2010, 34 (10) : 1358 - 1365
  • [44] Fms Like Tyrosine Kinase (FLT3) and Nucleophosmin 1 (NPM1) Mutations in De Novo Normal Karyotype Acute Myeloid Leukemia (AML)
    Dunna, Nageswara Rao
    Rajappa, Senthil
    Digumarti, Raghunadharao
    Vure, Sugunakar
    Kagita, Sailaja
    Damineni, Surekha
    Rao, V. R.
    Yadav, Satish Kumar
    Ravuri, Rajasekhara Reddy
    Satti, Vishnupriya
    ASIAN PACIFIC JOURNAL OF CANCER PREVENTION, 2010, 11 (06) : 1811 - 1816
  • [45] Internal tandem duplication and Asp835 mutation of the FMS-like tyrosine kinase 3 (FLT3) gene in children with acute promyelocytic leukemia
    Hoshi, Y
    Rikiishi, T
    Fujii, K
    Suwabe, N
    Imaizumi, M
    Iinuma, K
    Tsurusawa, M
    Horibe, K
    Hara, J
    Tsukimoto, I
    EXPERIMENTAL HEMATOLOGY, 2005, 33 (07) : 73 - 73
  • [46] KI2011 is a novel potent FLT3 tyrosine kinase inhibitor in acute myeloid leukemia cells with FLT3-mutation
    Ryu, Hwani
    Song, Jie-Young
    Ahn, Jiyeon
    CANCER RESEARCH, 2018, 78 (13)
  • [47] Targeting DNA Damage and Repair in Acute Myeloid Leukemia Carrying Internal Tandem Duplication of Fms-like Tyrosine Kinase 3 (FLT3-ITD) - a Mechanistic Study
    Nelson, Ka Lam
    Lynn, Claire
    Leung, Thomas Wing Yan
    So, Eric Chi Wai
    Leung, Anskar Yu Hung
    BLOOD, 2019, 134
  • [48] Nuclear NFATc1 Causes Development of Fms-like Receptor Tyrosine Kinase 3 Receptor (FLT3) Internal Tandem Duplication Mutation-Positive (FLT3-ITD) Acute Myeloid Leukemia (AML) and Mediates Drug Resistance
    Solovey, Maria A.
    Wang, Ying
    Gattenloehner, Stefan
    Hessmann, Elisabeth
    Metzelder, Stephan
    Michel, Christian
    Ellenrieder, Volker
    Goethert, Joachim R.
    Neubauer, Andreas
    Burchert, Andreas
    BLOOD, 2016, 128 (22)
  • [49] Concurrent FLT3 Inhibitor and IDH Inhibitor Therapy in Patients with Acute Myeloid Leukemia (AML)
    Fathi, Amir T.
    Perl, Alexander E.
    Levis, Mark
    Smith, Catherine C.
    Brunner, Andrew M.
    Takahashi, Koichi
    Hock, Hanno R.
    Hobbs, Gabriela S.
    Narayan, Rupa
    Moran, Jenna A.
    Bergeron, Meghan
    Foster, Julia E.
    Daver, Naval
    DiNardo, Courtney D.
    BLOOD, 2020, 136
  • [50] Pim kinases modulate resistance to FLT3 tyrosine kinase inhibitors in FLT3-ITD acute myeloid leukemia
    Green, Alexa S.
    Maciel, Thiago T.
    Hospital, Marie-Anne
    Yin, Chae
    Mazed, Fetta
    Townsend, Elizabeth C.
    Pilorge, Sylvain
    Lambert, Mireille
    Paubelle, Etienne
    Jacquel, Arnaud
    Zylbersztejn, Florence
    Decroocq, Justine
    Poulain, Laury
    Sujobert, Pierre
    Jacque, Nathalie
    Adam, Kevin
    So, Jason C. C.
    Kosmider, Olivier
    Auberger, Patrick
    Hermine, Olivier
    Weinstock, David M.
    Lacombe, Catherine
    Mayeux, Patrick
    Vanasse, Gary J.
    Leung, Anskar Y.
    Moura, Ivan C.
    Bouscary, Didier
    Tamburini, Jerome
    SCIENCE ADVANCES, 2015, 1 (08):
12345