The catalytic activity of TET2 is essential for its myeloid malignancy-suppressive function in hematopoietic stem/progenitor cells

被引:22
|
作者
Zhao, Z. [1 ,2 ]
Chen, S. [1 ]
Zhu, X. [1 ]
Pan, F. [1 ]
Li, R. [3 ,4 ,5 ]
Zhou, Y. [3 ,4 ,5 ]
Yuan, W. [3 ,4 ,5 ]
Ni, H. [6 ]
Yang, F-C [1 ]
Xu, M. [1 ]
机构
[1] Univ Miami, Miller Sch Med, Dept Biochem & Mol Biol, Sylvester Comprehens Canc Ctr, Miami, FL 33136 USA
[2] Tianjin Med Univ Canc Inst & Hosp, Dept Hematol & Oncol, Natl Clin Res Ctr Canc, Key Lab Canc Prevent & Therapy, Tianjin, Peoples R China
[3] Chinese Acad Med Sci, Inst Hematol, State Key Lab Expt Hematol, Tianjin, Peoples R China
[4] Chinese Acad Med Sci, Blood Dis Hosp, State Key Lab Expt Hematol, Tianjin, Peoples R China
[5] Peking Union Med Coll, Tianjin, Peoples R China
[6] Univ Illinois, Dept Pathol, Chicago, IL USA
关键词
MAMMALIAN DNA; STEM-CELLS; MUTATIONS; MICE; 5-CARBOXYLCYTOSINE; 5-METHYLCYTOSINE; LEADS;
D O I
10.1038/leu.2016.56
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
引用
收藏
页码:1784 / 1788
页数:6
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