The catalytic activity of TET2 is essential for its myeloid malignancy-suppressive function in hematopoietic stem/progenitor cells

被引:22
|
作者
Zhao, Z. [1 ,2 ]
Chen, S. [1 ]
Zhu, X. [1 ]
Pan, F. [1 ]
Li, R. [3 ,4 ,5 ]
Zhou, Y. [3 ,4 ,5 ]
Yuan, W. [3 ,4 ,5 ]
Ni, H. [6 ]
Yang, F-C [1 ]
Xu, M. [1 ]
机构
[1] Univ Miami, Miller Sch Med, Dept Biochem & Mol Biol, Sylvester Comprehens Canc Ctr, Miami, FL 33136 USA
[2] Tianjin Med Univ Canc Inst & Hosp, Dept Hematol & Oncol, Natl Clin Res Ctr Canc, Key Lab Canc Prevent & Therapy, Tianjin, Peoples R China
[3] Chinese Acad Med Sci, Inst Hematol, State Key Lab Expt Hematol, Tianjin, Peoples R China
[4] Chinese Acad Med Sci, Blood Dis Hosp, State Key Lab Expt Hematol, Tianjin, Peoples R China
[5] Peking Union Med Coll, Tianjin, Peoples R China
[6] Univ Illinois, Dept Pathol, Chicago, IL USA
关键词
MAMMALIAN DNA; STEM-CELLS; MUTATIONS; MICE; 5-CARBOXYLCYTOSINE; 5-METHYLCYTOSINE; LEADS;
D O I
10.1038/leu.2016.56
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
引用
收藏
页码:1784 / 1788
页数:6
相关论文
共 50 条
  • [31] The Long Non-Coding RNA MALAT1 Is Necessary for Hematopoietic Stem and Progenitor Cell Expansion and Preleukemic Myeloproliferation in TET2 Deficient Myeloid Neoplasms
    Ben-Crentsil, Nana Adjoa
    Quintana-Gonzalez, Ariel
    Balasis, Maria E.
    Newman, Hannah
    Kruer, Traci L.
    Sun, Lei
    Letson, Christopher
    Dhawan, Abhishek
    Talati, Chetasi
    Ferrall-Fairbanks, Meghan
    Vedder, Alexis
    McGraw, Kathy
    Komrokji, Rami S.
    Ma, Li
    Padron, Eric
    BLOOD, 2022, 140 : 1991 - 1993
  • [32] Lymphoid-biased hematopoietic stem cells and myeloid-biased hematopoietic progenitor cells have radioprotection activity
    Zhang, Shanshan
    O'Neill, Aled
    Xie, Miner
    Wu, Peng
    Wang, Xiaofang
    Bai, Haitao
    Dong, Fang
    Wang, Jinhong
    Zhang, Qingyun
    Suda, Toshio
    Ema, Hideo
    BLOOD SCIENCE, 2021, 3 (04): : 113 - 121
  • [33] Ten-Eleven-Translocation 2 (TET2) negatively regulates homeostasis and differentiation of hematopoietic stem cells in mice
    Ko, Myunggon
    Bandukwala, Hozefa S.
    An, Jungeun
    Lamperti, Edward D.
    Thompson, Elizabeth C.
    Hastie, Ryan
    Tsangaratou, Angeliki
    Rajewsky, Klaus
    Koralov, Sergei B.
    Rao, Anjana
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (35) : 14566 - 14571
  • [34] Fhl2 Regulates The Function Of Hematopoietic Stem/Progenitor Cells
    Hou, Yu
    Qian, Zhijian
    BLOOD, 2013, 122 (21)
  • [35] Residual Wild-Type Tet2/Tet3 Allele Is the Savior Preventing Mouse Hematopoietic Progenitor Cells from Leukemia Development
    Shrestha, Raksha
    Koichiro, Maie
    Sakata-Yanagimoto, Mamiko
    Bernard, Olivier
    Matsui, Hirotaka
    Nakajima-Takagi, Yaeko
    Kato, Takayasu
    Koseki, Haruhiko
    Iwama, Atsushi
    Chiba, Shigeru
    BLOOD, 2018, 132
  • [36] Physioxia-induced downregulation of Tet2 in hematopoietic stem cells contributes to enhanced self-renewal
    Aljoufi, Arafat
    Zhang, Chi
    Ropa, James
    Chang, Wennan
    Palam, Lakshmi Reddy
    Cooper, Scott
    Ramdas, Baskar
    Capitano, Maegan L.
    Broxmeyer, Hal E.
    Kapur, Reuben
    BLOOD, 2022, 140 (11) : 1263 - 1277
  • [37] Tetrahydroxy stilbene glucoside rejuvenates aging hematopoietic stem cells with predilection for lymphoid differentiation via AMPK and Tet2
    Gao, Dan
    Yi, Wei-wei
    Liu, Bo
    Zhang, Cong-en
    Yang, Cui-cui
    Zeng, Li
    Li, Lin
    Luo, Guangbin
    Zhang, Lan
    Ju, Zhen-yu
    Wang, Jia-bo
    JOURNAL OF ADVANCED RESEARCH, 2025, 70 : 515 - 529
  • [38] Tet2 disruption leads to enhanced self-renewal and altered differentiation of fetal liver hematopoietic stem cells
    Kunimoto, Hiroyoshi
    Fukuchi, Yumi
    Sakurai, Masatoshi
    Sadahira, Ken
    Ikeda, Yasuo
    Okamoto, Shinichiro
    Nakajima, Hideaki
    SCIENTIFIC REPORTS, 2012, 2
  • [39] Tet2 disruption leads to enhanced self-renewal and altered differentiation of fetal liver hematopoietic stem cells
    Hiroyoshi Kunimoto
    Yumi Fukuchi
    Masatoshi Sakurai
    Ken Sadahira
    Yasuo Ikeda
    Shinichiro Okamoto
    Hideaki Nakajima
    Scientific Reports, 2
  • [40] Hyperactive Nras and Dose Reduction of Tet2 Collaborate to Dys-Regulate Hematopoietic Stem Cells and Promote Leukemogenesis
    Jin, Xi
    Qin, Tingting
    Bailey, Nathanael G.
    Zhao, Meiling
    Yang, Kevin B.
    Ng, Victor
    Liu, Lu
    Coolon, Rosemary
    Ney, Gina
    Figueroa, Maria E.
    Li, Qing
    BLOOD, 2016, 128 (22)