The catalytic activity of TET2 is essential for its myeloid malignancy-suppressive function in hematopoietic stem/progenitor cells

被引：22
|
作者：
Zhao, Z. [1 ,2 ]
Chen, S. [1 ]
Zhu, X. [1 ]
Pan, F. [1 ]
Li, R. [3 ,4 ,5 ]
Zhou, Y. [3 ,4 ,5 ]
Yuan, W. [3 ,4 ,5 ]
Ni, H. [6 ]
Yang, F-C [1 ]
Xu, M. [1 ]
机构：
[1] Univ Miami, Miller Sch Med, Dept Biochem & Mol Biol, Sylvester Comprehens Canc Ctr, Miami, FL 33136 USA
[2] Tianjin Med Univ Canc Inst & Hosp, Dept Hematol & Oncol, Natl Clin Res Ctr Canc, Key Lab Canc Prevent & Therapy, Tianjin, Peoples R China
[3] Chinese Acad Med Sci, Inst Hematol, State Key Lab Expt Hematol, Tianjin, Peoples R China
[4] Chinese Acad Med Sci, Blood Dis Hosp, State Key Lab Expt Hematol, Tianjin, Peoples R China
[5] Peking Union Med Coll, Tianjin, Peoples R China
[6] Univ Illinois, Dept Pathol, Chicago, IL USA
来源：
LEUKEMIA | 2016年 / 30卷 / 08期
关键词：
MAMMALIAN DNA; STEM-CELLS; MUTATIONS; MICE; 5-CARBOXYLCYTOSINE; 5-METHYLCYTOSINE; LEADS;
D O I：
10.1038/leu.2016.56
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
引用
收藏
页码：1784 / 1788
页数：6
相关论文
共 50 条
  • [1] The catalytic activity of TET2 is essential for its myeloid malignancy-suppressive function in hematopoietic stem/progenitor cells
    Z Zhao
    S Chen
    X Zhu
    F Pan
    R Li
    Y Zhou
    W Yuan
    H Ni
    F-C Yang
    M Xu
    Leukemia, 2016, 30 : 1784 - 1788
  • [2] Non-catalytic Roles of Tet2 Are Essential to Regulate Hematopoietic Stem and Progenitor Cell Homeostasis
    Ito, Kyoko
    Lee, Joun
    Chrysanthou, Stephanie
    Zhao, Yilin
    Josephs, Katherine
    Sato, Hiroyo
    Teruya-Feldstein, Julie
    Zheng, Deyou
    Dawlaty, Meelad M.
    Ito, Keisuke
    CELL REPORTS, 2019, 28 (10): : 2480 - +
  • [3] Tet2 Deficiency Rejuvenates Hematopoietic Stem and Progenitor Cells during Ageing
    Hong, Tingting
    Li, Shengli
    Fang, Shaohai
    Guzman, Anna
    Han, Wei
    Zhou, Yubin
    Han, Leng
    Goodell, Margaret
    Huang, Yun
    BLOOD, 2020, 136
  • [4] TET2 modulates spatial relocalization of heterochromatin in aged hematopoietic stem and progenitor cells
    Tingting Hong
    Jia Li
    Lei Guo
    Maryn Cavalier
    Tianlu Wang
    Yaling Dou
    Aaron DeLaFuente
    Shaohai Fang
    Anna Guzman
    Katherina Wohlan
    Chiraag Kapadia
    Carina Rosas
    Yaling Yang
    C. Cameron Yin
    Shaoying Li
    M. James You
    Xiaodong Cheng
    Margaret A. Goodell
    Yubin Zhou
    Yun Huang
    Nature Aging, 2023, 3 : 1387 - 1400
  • [5] TET2 modulates spatial relocalization of heterochromatin in aged hematopoietic stem and progenitor cells
    Hong, Tingting
    Li, Jia
    Guo, Lei
    Cavalier, Maryn
    Wang, Tianlu
    Dou, Yaling
    DeLaFuente, Aaron
    Fang, Shaohai
    Guzman, Anna
    Wohlan, Katherina
    Kapadia, Chiraag
    Rosas, Carina
    Yang, Yaling
    Yin, C. Cameron
    Li, Shaoying
    You, M. James
    Cheng, Xiaodong
    Goodell, Margaret A.
    Zhou, Yubin
    Huang, Yun
    NATURE AGING, 2023, 3 (11): : 1387 - +
  • [6] TET2 is essential for survival and hematopoietic stem cell homeostasis
    K Shide
    T Kameda
    H Shimoda
    T Yamaji
    H Abe
    A Kamiunten
    M Sekine
    T Hidaka
    K Katayose
    Y Kubuki
    S Yamamoto
    T Miike
    H Iwakiri
    S Hasuike
    K Nagata
    K Marutsuka
    A Iwama
    T Matsuda
    A Kitanaka
    K Shimoda
    Leukemia, 2012, 26 : 2216 - 2223
  • [7] TET2 is essential for survival and hematopoietic stem cell homeostasis
    Shide, K.
    Kameda, T.
    Shimoda, H.
    Yamaji, T.
    Abe, H.
    Kamiunten, A.
    Sekine, M.
    Hidaka, T.
    Katayose, K.
    Kubuki, Y.
    Yamamoto, S.
    Miike, T.
    Iwakiri, H.
    Hasuike, S.
    Nagata, K.
    Marutsuka, K.
    Iwama, A.
    Matsuda, T.
    Kitanaka, A.
    Shimoda, K.
    LEUKEMIA, 2012, 26 (10) : 2216 - 2223
  • [8] Distinct and opposite effects of leukemogenic Idh and Tet2 mutations in hematopoietic stem and progenitor cells
    Fortin, Jerome
    Chiang, Ming-Feng
    Meydan, Cem
    Foox, Jonathan
    Ramachandran, Parameswaran
    Leca, Julie
    Lemonnier, Francois
    Li, Wanda Y.
    Gams, Miki S.
    Sakamoto, Takashi
    Chu, Mandy
    Tobin, Chantal
    Laugesen, Eric
    Robinson, Troy M.
    You-Ten, Annick
    Butler, Daniel J.
    Berger, Thorsten
    Minden, Mark D.
    Levine, Ross L.
    Guidos, Cynthia J.
    Melnick, Ari M.
    Mason, Christopher E.
    Mak, Tak W.
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2023, 120 (04)
  • [9] Loss of TET2 in human hematopoietic stem cells alters the development and function of neutrophils
    Encabo, Hector Huerga
    Aramburu, Iker Valle
    Garcia-Albornoz, Manuel
    Piganeau, Marion
    Wood, Henry
    Song, Anna
    Ferrelli, Alessandra
    Sharma, Aneesh
    Minutti, Carlos M.
    Domart, Marie-Charlotte
    Papazoglou, Despoina
    Gurashi, Kristian
    Sopena, Miriam Llorian
    Goldstone, Robert
    Fallesen, Todd
    Wang, Qian
    Ariza-McNaughton, Linda
    Wiseman, Daniel H.
    Batta, Kiran
    Gupta, Rajeev
    Papayannopoulos, Venizelos
    Bonnet, Dominique
    CELL STEM CELL, 2023, 30 (06) : 781 - +
  • [10] Oncogenic N-Ras and Tet2 haploinsufficiency collaborate to dysregulate hematopoietic stem and progenitor cells
    Jin, Xi
    Qin, Tingting
    Zhao, Meiling
    Bailey, Nathanael
    Liu, Lu
    Yang, Kevin
    Ng, Victor
    Higashimoto, Tomoyasu
    Coolon, Rosemary
    Ney, Gina
    Figueroa, Maria E.
    Li, Qing
    BLOOD ADVANCES, 2018, 2 (11) : 1259 - 1271
12345